Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1005616..1007303 Replicon chromosome
Accession NZ_CP009237
Organism Glaesserella parasuis strain KL0318

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JT17_RS04845 Protein ID WP_016528417.1
Coordinates 1005960..1007303 (-) Length 448 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JT17_RS04840 Protein ID WP_005713145.1
Coordinates 1005616..1005960 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT17_RS04820 1001684..1002634 - 951 WP_005713153.1 ribose-phosphate pyrophosphokinase -
JT17_RS04825 1002662..1003507 - 846 WP_044009186.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
JT17_RS04830 1003509..1004141 - 633 WP_005713149.1 lipoprotein insertase outer membrane protein LolB -
JT17_RS04835 1004262..1005587 - 1326 WP_044009187.1 ATP-dependent RNA helicase SrmB -
JT17_RS04840 1005616..1005960 - 345 WP_005713145.1 helix-turn-helix domain-containing protein Antitoxin
JT17_RS04845 1005960..1007303 - 1344 WP_016528417.1 type II toxin-antitoxin system HipA family toxin Toxin
JT17_RS04850 1007417..1007854 - 438 WP_044009188.1 ribosomal protein S18-alanine N-acetyltransferase -
JT17_RS04855 1008096..1008341 - 246 WP_005713138.1 M23 family metallopeptidase -
JT17_RS04860 1008538..1008951 - 414 WP_005713136.1 DNA polymerase III subunit psi -
JT17_RS04865 1009034..1009975 + 942 WP_021115536.1 16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC -
JT17_RS04870 1010124..1012301 + 2178 WP_044009189.1 bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(161-407)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 448 a.a.        Molecular weight: 51022.91 Da        Isoelectric Point: 4.9426

>T48581 WP_016528417.1 NZ_CP009237:c1007303-1005960 [Glaesserella parasuis]
MQIEPLTLQAYIADRWQDIAILTFQADYSLNDFSYLYDLAEILSDNDKAVSFNYPVEFFPYRSVSGWFAFLDDIVPSGAS
RRYWLQKLDIAHLPTAQQNYLLLKQGTIAPVGHLRVKQAVSSFIENEPPRLFEIDDVINRQADFLEYANQRGAMAGGATG
AGGEAPKLLLRQTATQQVWIDNLQQGDAADDFYLVKFPRGKRSAIDCDILRAEFHYYHELASMGFDTIDTTKMRLEEGER
YPSLWLPRFDVYRNEQGKMARYAVESVYAMLEKGAGSLLDHEKVIRQLIAKIENSHLVETGMAFDKQAFVIEWVRRDLLN
IAFGNSDNHGRNTAFLRNQNRIWLAPIYDFAPMKADPEGIPRTTMWDSKSHPALELGGEYRFDLIAEQLDDLCSADKLLD
ALRQTAQQLVGLKARLEARGVPTAILTYPSISLDYLPEKLQRWQLLS

Download         Length: 1344 bp

>T48581 NZ_CP009237:c1007303-1005960 [Glaesserella parasuis]
ATGCAAATCGAACCGCTTACACTTCAGGCCTATATTGCTGATCGTTGGCAGGATATTGCTATTTTGACCTTTCAGGCTGA
TTATAGCCTCAATGATTTTAGCTATCTCTATGATTTAGCAGAGATTTTAAGTGATAATGATAAGGCAGTTTCATTTAACT
ATCCTGTGGAGTTTTTCCCATACCGTAGTGTATCGGGCTGGTTTGCATTTTTAGATGATATAGTTCCTTCTGGAGCAAGT
CGGCGTTATTGGTTGCAAAAACTTGATATTGCTCATTTGCCGACAGCTCAACAAAACTATTTGTTATTAAAACAAGGTAC
GATTGCACCTGTCGGGCATTTACGAGTGAAGCAAGCGGTCAGTTCTTTTATCGAAAATGAACCCCCTCGCTTATTTGAAA
TAGATGATGTTATCAATCGCCAAGCTGATTTTTTGGAATATGCTAATCAGCGTGGGGCAATGGCTGGCGGTGCAACGGGG
GCTGGTGGCGAAGCGCCGAAATTATTGCTACGCCAAACAGCCACTCAGCAAGTTTGGATTGATAATCTACAACAAGGTGA
CGCTGCCGACGATTTCTATTTAGTCAAGTTTCCGCGTGGAAAACGCAGTGCAATAGATTGCGACATATTGAGAGCTGAAT
TTCACTATTACCACGAATTAGCCTCAATGGGTTTTGATACCATTGATACGACAAAAATGCGGTTGGAAGAGGGCGAACGT
TACCCGTCGTTATGGTTACCTCGCTTTGATGTTTATCGTAATGAACAGGGGAAAATGGCTCGATATGCCGTTGAATCTGT
TTATGCTATGTTAGAAAAAGGGGCTGGCTCTTTGCTGGATCACGAAAAGGTTATTCGTCAGTTGATTGCCAAAATTGAAA
ATTCTCACCTAGTTGAAACAGGAATGGCTTTTGATAAACAGGCTTTTGTGATCGAGTGGGTAAGGCGAGATTTATTGAAT
ATCGCCTTTGGAAATAGCGATAATCACGGGCGAAATACCGCTTTCTTACGCAATCAAAATCGTATTTGGCTTGCTCCAAT
TTATGATTTTGCCCCAATGAAAGCGGATCCTGAAGGCATTCCTCGTACGACAATGTGGGATAGTAAAAGTCACCCTGCAT
TAGAATTAGGCGGTGAATATCGTTTTGATCTGATTGCAGAACAGCTTGATGATTTATGTTCAGCCGACAAGTTATTGGAT
GCTTTGCGTCAAACGGCTCAACAGCTTGTCGGGCTTAAAGCACGTTTAGAAGCAAGGGGCGTTCCAACGGCGATTTTGAC
GTACCCTTCAATCAGTTTGGACTATTTACCTGAAAAATTACAACGTTGGCAATTATTATCATAA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13207.48 Da        Isoelectric Point: 10.2782

>AT48581 WP_005713145.1 NZ_CP009237:c1005960-1005616 [Glaesserella parasuis]
MEEIKQARASKSKKTLDIYQRATVRDEIARKLLLNEMSLGQALKYLRLHLLAMKQERYAEIVKVSRKTLSDLENDKGNYS
IDIINQVLRPFELQLGVVPINKTLLRQVLNEQAV

Download         Length: 345 bp

>AT48581 NZ_CP009237:c1005960-1005616 [Glaesserella parasuis]
ATGGAAGAGATCAAACAGGCGAGAGCCTCTAAAAGTAAAAAAACGTTAGATATTTATCAGAGAGCGACTGTGCGAGACGA
AATTGCTCGTAAGCTATTGCTCAATGAGATGAGTTTAGGGCAGGCGTTGAAATATCTACGTTTACATCTACTGGCAATGA
AACAAGAGCGTTATGCGGAGATTGTCAAAGTTTCTCGCAAAACGTTATCTGATTTAGAAAATGATAAGGGAAATTACAGT
ATTGATATTATCAATCAGGTGTTACGCCCCTTTGAATTACAGCTTGGCGTTGTGCCAATAAACAAAACATTACTCAGACA
AGTTTTAAATGAACAAGCGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References