Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-stbD/ParE-DnaT
Location 693184..693719 Replicon chromosome
Accession NZ_CP009237
Organism Glaesserella parasuis strain KL0318

Toxin (Protein)


Gene name relE Uniprot ID A0A836YZW4
Locus tag JT17_RS03360 Protein ID WP_016528228.1
Coordinates 693184..693468 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A836Z1U9
Locus tag JT17_RS03365 Protein ID WP_010785924.1
Coordinates 693465..693719 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT17_RS03340 688251..689072 - 822 WP_044009099.1 PHP domain-containing protein -
JT17_RS03345 689148..690119 - 972 WP_012621529.1 IS110 family transposase -
JT17_RS03350 690383..691342 - 960 WP_044009100.1 S-adenosyl-l-methionine hydroxide adenosyltransferase family protein -
JT17_RS03355 691425..692975 - 1551 WP_016528227.1 exodeoxyribonuclease I -
JT17_RS03360 693184..693468 - 285 WP_016528228.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JT17_RS03365 693465..693719 - 255 WP_010785924.1 plasmid stability protein StbD Antitoxin
JT17_RS03370 693836..694591 - 756 WP_010785925.1 ABC transporter permease -
JT17_RS03375 694613..695509 - 897 WP_044009101.1 ABC transporter ATP-binding protein -
JT17_RS03380 695515..697532 - 2018 Protein_678 DNA polymerase III subunit gamma/tau -
JT17_RS03385 697620..698162 - 543 WP_005712695.1 adenine phosphoribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11276.27 Da        Isoelectric Point: 10.5362

>T48579 WP_016528228.1 NZ_CP009237:c693468-693184 [Glaesserella parasuis]
MSYTIEFIPSAEKEFRKLSLDLRKQFIEKLKERAENPRVESAKLRGMKDCYKIKLRNAGYRLVYQVIDERIVIKVVAQGK
RERNDVYQKVQLRL

Download         Length: 285 bp

>T48579 NZ_CP009237:c693468-693184 [Glaesserella parasuis]
ATGAGCTATACCATTGAATTTATCCCATCAGCAGAAAAAGAGTTCCGTAAACTAAGCTTAGATTTAAGAAAACAATTTAT
CGAAAAACTTAAAGAAAGAGCTGAAAATCCGCGTGTAGAAAGTGCTAAACTTCGTGGAATGAAAGATTGTTATAAAATCA
AATTGCGTAATGCAGGCTATCGTTTGGTATATCAAGTGATTGATGAACGTATTGTAATCAAAGTGGTTGCACAGGGAAAA
AGGGAGCGCAACGACGTTTACCAAAAAGTACAATTACGTTTATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9333.70 Da        Isoelectric Point: 4.4131

>AT48579 WP_010785924.1 NZ_CP009237:c693719-693465 [Glaesserella parasuis]
MPSVILTNTVASITELKTNPMATFNAAGGEAIAILNRNEPAFYCVPPHIYEYLIELADDAELAKLVEERQHEKSYKVDLA
DLLK

Download         Length: 255 bp

>AT48579 NZ_CP009237:c693719-693465 [Glaesserella parasuis]
ATGCCAAGTGTTATTTTAACCAATACCGTTGCGAGTATTACAGAACTAAAGACAAATCCAATGGCGACATTCAATGCGGC
AGGCGGTGAGGCAATTGCAATTTTAAACCGAAATGAACCCGCTTTTTATTGTGTACCACCGCATATTTATGAATATCTCA
TTGAGCTTGCTGATGATGCAGAATTAGCAAAATTAGTGGAAGAACGCCAACACGAAAAAAGCTACAAAGTGGATTTAGCG
GATTTATTAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836YZW4

Antitoxin

Source ID Structure
AlphaFold DB A0A836Z1U9

References