Detailed information of TA system TA048576

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 64299..64921
• Replicon: chromosome
• Accession: NZ_CP009237
• Organism: Glaesserella parasuis strain KL0318

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A836YYE8
• Locus tag: JT17_RS00320
• Protein ID: WP_005715063.1
• Coordinates: 64739..64921 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A837B0B6
• Locus tag: JT17_RS00315
• Protein ID: WP_005715065.1
• Coordinates: 64299..64712 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JT17_RS00280	60197..60880	-	684	WP_005714533.1	helix-turn-helix transcriptional regulator	-
JT17_RS00285	61011..61211	+	201	WP_005714531.1	helix-turn-helix domain-containing protein	-
JT17_RS00290	61232..61508	+	277	Protein_58	hypothetical protein	-
JT17_RS00295	61553..62278	+	726	WP_016527921.1	Rha family transcriptional regulator	-
JT17_RS00300	62275..63105	+	831	WP_044008916.1	hypothetical protein	-
JT17_RS00305	63105..63779	+	675	WP_052157598.1	hypothetical protein	-
JT17_RS00310	63837..64265	+	429	WP_044009517.1	recombination protein NinB	-
JT17_RS00315	64299..64712	-	414	WP_005715065.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JT17_RS00320	64739..64921	-	183	WP_005715063.1	type II toxin-antitoxin system HicA family toxin	Toxin
JT17_RS00325	65169..65738	+	570	WP_044008917.1	recombination protein NinG	-
JT17_RS00330	65735..66112	+	378	WP_044008918.1	antitermination protein	-
JT17_RS00335	66139..66330	-	192	WP_035491811.1	hypothetical protein	-
JT17_RS00340	66920..67510	+	591	Protein_68	phage antirepressor N-terminal domain-containing protein	-
JT17_RS00345	68196..68759	-	564	WP_005714778.1	hypothetical protein	-
JT17_RS00350	68873..69148	+	276	WP_010786311.1	hypothetical protein	-
JT17_RS00355	69123..69668	+	546	WP_026916880.1	lysozyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	50790..137704	86914

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-130)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6678.80 Da
• Isoelectric Point: 10.6602

>T48576 WP_005715063.1 NZ_CP009237:c64921-64739 [Glaesserella parasuis]
VDSKTIIKMIEADGWYLVATSGSHHQFKHPTKQGRVTVPHPKKDLKKGTELSILKQAGLK

Nucleotide

• Length: 183 bp

>T48576 NZ_CP009237:c64921-64739 [Glaesserella parasuis]
GTGGATAGCAAAACCATAATTAAAATGATTGAAGCGGACGGTTGGTACTTAGTTGCAACAAGTGGAAGCCACCATCAATT
CAAACATCCAACTAAACAAGGGCGAGTAACAGTGCCTCATCCGAAAAAGGATTTAAAAAAAGGAACTGAACTCTCAATAC
TTAAACAAGCGGGGCTAAAATAG

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15401.47 Da
• Isoelectric Point: 4.3988

>AT48576 WP_005715065.1 NZ_CP009237:c64712-64299 [Glaesserella parasuis]
MLYPIAIEPGDETHAYGVIVPDIPGCFSAGDTLEEAYQNVKEAIVFHLEGLVEDGEEIPMPTSIDNHRKNPDFAEYDFFF
GFVDVDISHLLGKAERINITLPSYLIKRIDDFVAVHKEYKNRSNFLAKIAADKILTA

Nucleotide

• Length: 414 bp

>AT48576 NZ_CP009237:c64712-64299 [Glaesserella parasuis]
ATGTTATACCCAATTGCAATTGAACCAGGTGACGAAACTCACGCTTACGGCGTTATCGTGCCTGATATTCCAGGGTGCTT
CTCTGCTGGCGATACCCTCGAAGAAGCATATCAAAATGTCAAAGAAGCCATCGTGTTCCACCTTGAAGGCTTAGTTGAAG
ATGGAGAAGAAATTCCGATGCCAACCTCCATTGATAACCACCGCAAAAACCCTGATTTTGCAGAATATGACTTCTTTTTC
GGCTTTGTTGATGTTGATATTAGCCATTTACTCGGCAAAGCCGAACGCATCAACATCACCCTCCCTAGCTATCTCATCAA
ACGCATTGATGATTTTGTTGCCGTTCACAAAGAGTATAAAAACCGTAGCAACTTCTTAGCTAAAATCGCAGCGGATAAAA
TCTTAACCGCTTAA

Structures

Toxin

• AlphaFold DB: A0A836YYE8

Antitoxin

• AlphaFold DB: A0A837B0B6