Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2145231..2145796 Replicon chromosome
Accession NZ_CP009228
Organism Treponema putidum strain OMZ 758 (ATCC 700334)

Toxin (Protein)


Gene name mazF Uniprot ID A0A562SDD8
Locus tag JO40_RS09810 Protein ID WP_044979180.1
Coordinates 2145458..2145796 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A562SC65
Locus tag JO40_RS09805 Protein ID WP_044979179.1
Coordinates 2145231..2145464 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JO40_RS09775 2140700..2141188 + 489 WP_044979173.1 hypothetical protein -
JO40_RS09780 2141705..2142079 + 375 WP_044979174.1 hypothetical protein -
JO40_RS12905 2142231..2142929 + 699 WP_010690396.1 hypothetical protein -
JO40_RS09790 2143153..2143830 + 678 WP_044979175.1 hypothetical protein -
JO40_RS09795 2143975..2144283 + 309 WP_044979176.1 nucleotidyltransferase family protein -
JO40_RS09800 2144267..2144623 + 357 WP_044979178.1 DUF86 domain-containing protein -
JO40_RS09805 2145231..2145464 + 234 WP_044979179.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JO40_RS09810 2145458..2145796 + 339 WP_044979180.1 endoribonuclease MazF Toxin
JO40_RS09815 2145971..2146450 + 480 WP_044979181.1 hypothetical protein -
JO40_RS09820 2147038..2147283 + 246 WP_044979182.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
JO40_RS09825 2147283..2147531 + 249 WP_044979183.1 type II toxin-antitoxin system RelE/ParE family toxin -
JO40_RS09830 2147700..2148584 - 885 WP_044979184.1 GTPase Era -
JO40_RS09835 2148586..2149434 - 849 WP_044979185.1 RnfABCDGE type electron transport complex subunit B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-110)

Antitoxin

Antitoxin PemI-like

(1-77)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12808.66 Da        Isoelectric Point: 6.6952

>T48569 WP_044979180.1 NZ_CP009228:2145458-2145796 [Treponema putidum]
MVNSNYVPDRGDLVWLDFTPQAGHEQKGRRPAICISQKRYNQKVGLALFCPITSHIKGYPFEIVLDNHSINGCILSDQVK
NLDYKKRSCDFIEKTTEEEINAVVDNIKLLIE

Download         Length: 339 bp

>T48569 NZ_CP009228:2145458-2145796 [Treponema putidum]
ATGGTGAATTCAAATTATGTTCCCGATAGAGGCGATTTAGTTTGGCTTGATTTTACCCCGCAAGCAGGACATGAGCAGAA
AGGTCGTCGTCCTGCAATTTGCATTTCTCAAAAACGATACAATCAAAAAGTCGGACTTGCTTTATTTTGTCCTATTACAA
GCCATATAAAAGGCTATCCTTTTGAAATTGTATTGGATAATCATTCGATAAATGGCTGTATTCTTAGCGACCAAGTAAAG
AACCTTGATTATAAAAAAAGAAGTTGTGATTTTATAGAAAAAACAACAGAAGAAGAGATAAATGCTGTTGTAGATAATAT
AAAGTTGTTGATTGAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8588.81 Da        Isoelectric Point: 5.0035

>AT48569 WP_044979179.1 NZ_CP009228:2145231-2145464 [Treponema putidum]
MQVVVQKWGNSLGFRIPSLWAKDNNVKNGSKIEVIAEKGKIVILPQEKTLDDMLAMVTSENVHSEISTGYSVGNEEW

Download         Length: 234 bp

>AT48569 NZ_CP009228:2145231-2145464 [Treponema putidum]
ATGCAGGTTGTAGTTCAGAAATGGGGTAATAGTCTCGGGTTTAGAATACCCTCTCTTTGGGCAAAAGATAATAATGTAAA
GAATGGAAGCAAAATAGAAGTAATCGCAGAAAAAGGAAAAATAGTAATTCTTCCTCAGGAAAAAACCCTTGATGATATGC
TGGCAATGGTTACTTCTGAAAATGTTCATTCGGAAATCTCTACAGGTTATTCAGTAGGTAACGAAGAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A562SDD8

Antitoxin

Source ID Structure
AlphaFold DB A0A562SC65

References