Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1019599..1020224 Replicon chromosome
Accession NZ_CP009228
Organism Treponema putidum strain OMZ 758 (ATCC 700334)

Toxin (Protein)


Gene name vapC Uniprot ID A0A562S3C0
Locus tag JO40_RS04555 Protein ID WP_044978311.1
Coordinates 1019599..1019994 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A562S436
Locus tag JO40_RS04560 Protein ID WP_044978312.1
Coordinates 1019994..1020224 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JO40_RS04535 1015471..1016308 + 838 Protein_897 FAD-dependent thymidylate synthase -
JO40_RS04540 1016327..1018051 + 1725 WP_044978308.1 TrkH family potassium uptake protein -
JO40_RS04545 1018063..1018755 + 693 WP_044978309.1 TrkA family potassium uptake protein -
JO40_RS04550 1018766..1019518 + 753 WP_044978310.1 hypothetical protein -
JO40_RS04555 1019599..1019994 - 396 WP_044978311.1 type II toxin-antitoxin system VapC family toxin Toxin
JO40_RS04560 1019994..1020224 - 231 WP_044978312.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JO40_RS04565 1020423..1022195 + 1773 WP_044978313.1 ABC transporter ATP-binding protein/permease -
JO40_RS04570 1022254..1023252 + 999 WP_044978314.1 MoxR family ATPase -
JO40_RS04575 1023215..1024513 - 1299 WP_044978315.1 hemolysin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 15156.82 Da        Isoelectric Point: 9.7944

>T48567 WP_044978311.1 NZ_CP009228:c1019994-1019599 [Treponema putidum]
MYLLDTNICIFLKNKKSPNVLHKIKEKKHLGIYISSITVAELQFGVYNSKYIERNRIALIKFLTPFSILNFDDRDAEEFG
KIRTSLKNEGKIIGAYDMLIAAQALAKNLILVTDNTKEFCRIKNLTIEDWK

Download         Length: 396 bp

>T48567 NZ_CP009228:c1019994-1019599 [Treponema putidum]
ATGTACCTATTGGATACAAATATCTGTATATTTCTTAAAAATAAAAAAAGTCCTAATGTACTTCACAAAATTAAAGAGAA
GAAACACTTGGGAATTTACATTTCAAGTATTACTGTGGCAGAGTTACAGTTCGGCGTATACAATAGTAAATATATAGAAA
GAAATAGAATAGCATTAATAAAATTTTTAACACCTTTTTCTATTTTAAATTTTGATGATAGAGATGCCGAGGAATTTGGA
AAAATAAGGACCAGCCTAAAAAATGAAGGGAAAATTATAGGAGCCTATGATATGTTGATAGCGGCACAGGCACTAGCGAA
AAATCTAATTCTTGTTACCGACAATACAAAAGAATTCTGCCGTATAAAAAACTTAACCATAGAAGATTGGAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8826.97 Da        Isoelectric Point: 8.6155

>AT48567 WP_044978312.1 NZ_CP009228:c1020224-1019994 [Treponema putidum]
METAKLFQNGRSQAVRLPKKYNFSGTEVFIRRAGDSVILFPKNKEWETFLEGLNGFTDDFMEEGRNQPELQNRKGL

Download         Length: 231 bp

>AT48567 NZ_CP009228:c1020224-1019994 [Treponema putidum]
ATGGAAACGGCAAAATTATTCCAAAACGGCAGGAGTCAAGCAGTTAGGCTGCCTAAAAAATATAATTTTTCGGGAACCGA
GGTTTTTATCCGCAGAGCCGGAGATTCCGTTATTTTATTCCCCAAAAACAAGGAATGGGAAACATTTTTAGAAGGCTTAA
ACGGTTTTACCGACGATTTTATGGAGGAAGGAAGAAACCAGCCTGAATTACAGAATCGGAAAGGTTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A562S3C0

Antitoxin

Source ID Structure
AlphaFold DB A0A562S436

References