Detailed information of TA system TA048566

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): BrnTA/BrnT-BrnA
• Location: 1848424..1849000
• Replicon: chromosome
• Accession: NZ_CP009227
• Organism: Treponema sp. OMZ 838 strain OMZ 838 (ATCC 700772)

Toxin (Protein)

• Gene name: brnT
• Uniprot ID: -
• Locus tag: QI63_RS08435
• Protein ID: WP_044017233.1
• Coordinates: 1848424..1848744 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: -
• Locus tag: QI63_RS08440
• Protein ID: WP_044015505.1
• Coordinates: 1848725..1849000 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QI63_RS08410	1843540..1845333	+	1794	WP_044015497.1	hypothetical protein	-
QI63_RS08415	1845314..1845949	-	636	WP_044015498.1	PrsW family intramembrane metalloprotease	-
QI63_RS08420	1845963..1846616	-	654	WP_044015500.1	pyroglutamyl-peptidase I	-
QI63_RS08425	1846625..1847623	-	999	WP_044015502.1	DUF979 domain-containing protein	-
QI63_RS08430	1847616..1848290	-	675	WP_044015504.1	DUF969 domain-containing protein	-
QI63_RS08435	1848424..1848744	+	321	WP_044017233.1	BrnT family toxin	Toxin
QI63_RS08440	1848725..1849000	+	276	WP_044015505.1	BrnA antitoxin family protein	Antitoxin
QI63_RS08445	1849522..1851216	+	1695	WP_044015508.1	DEAD/DEAH box helicase	-
QI63_RS08450	1851311..1852126	+	816	WP_044015511.1	flagellar basal-body rod protein FlgF	-
QI63_RS08455	1852150..1852944	+	795	WP_016524140.1	flagellar basal-body rod protein FlgG	-
QI63_RS08460	1853164..1853688	+	525	WP_044015513.1	rod-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (14-92)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (30-81)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12222.82 Da
• Isoelectric Point: 4.6998

>T48566 WP_044017233.1 NZ_CP009227:1848424-1848744 [Treponema sp. OMZ 838]
MYIPLSMDDGLFEWDNEKNTINRQKHGIGFEEALLVFDDPFHIELYDAAHSDKEDRFLAIGTVLNVLVVLVVYTERNQRI
RIISARPATKKEKGLYYDAVNDTFGS

Nucleotide

• Length: 321 bp

>T48566 NZ_CP009227:1848424-1848744 [Treponema sp. OMZ 838]
ATGTATATACCATTAAGTATGGATGATGGGTTGTTTGAATGGGATAATGAAAAAAATACCATCAATAGGCAAAAACATGG
AATAGGTTTTGAAGAGGCTCTTTTGGTTTTTGATGATCCTTTTCATATAGAGTTATATGATGCCGCTCATTCCGATAAAG
AGGATAGATTTTTAGCTATCGGCACGGTTTTAAATGTTCTTGTTGTGTTGGTTGTTTATACGGAAAGAAATCAAAGGATA
AGAATTATATCGGCACGTCCTGCAACAAAAAAAGAAAAGGGGTTATATTATGATGCAGTCAATGACACTTTCGGAAGCTA
A

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10601.30 Da
• Isoelectric Point: 10.1326

>AT48566 WP_044015505.1 NZ_CP009227:1848725-1849000 [Treponema sp. OMZ 838]
MTLSEAKSMLTQQRIEQLKTLAEQPIDTSDIPELTQEEFFKMYRPIKKPLSIRLDSDIIVWLKSYGKGYQSRINTILRNA
MAAEKQAAQRR

Nucleotide

• Length: 276 bp

>AT48566 NZ_CP009227:1848725-1849000 [Treponema sp. OMZ 838]
ATGACACTTTCGGAAGCTAAAAGTATGCTTACACAACAGCGGATAGAACAGTTAAAAACACTTGCTGAACAACCGATTGA
TACATCTGATATTCCGGAGCTAACACAAGAAGAGTTTTTTAAAATGTATCGTCCAATAAAAAAACCGCTTTCAATCCGTC
TTGATTCGGACATTATTGTATGGCTTAAATCATACGGTAAGGGGTATCAAAGCCGAATAAATACCATTTTACGCAATGCA
ATGGCAGCGGAAAAACAAGCAGCACAGCGAAGATAA