Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1221829..1222421 Replicon chromosome
Accession NZ_CP009227
Organism Treponema sp. OMZ 838 strain OMZ 838 (ATCC 700772)

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QI63_RS05445 Protein ID WP_081984409.1
Coordinates 1222167..1222421 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QI63_RS05440 Protein ID WP_044014553.1
Coordinates 1221829..1222170 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QI63_RS05430 1219058..1220890 + 1833 WP_044014551.1 oligoendopeptidase F -
QI63_RS05435 1220909..1221805 + 897 WP_052185490.1 M28 family peptidase -
QI63_RS05440 1221829..1222170 - 342 WP_044014553.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QI63_RS05445 1222167..1222421 - 255 WP_081984409.1 type II toxin-antitoxin system HicA family toxin Toxin
QI63_RS05450 1222483..1223385 - 903 WP_200877771.1 Fic family protein -
QI63_RS05455 1223778..1224911 + 1134 WP_044014557.1 sigma-54 dependent transcriptional regulator -
QI63_RS05460 1224868..1225638 - 771 WP_052185491.1 RNA methyltransferase -
QI63_RS05465 1225745..1226461 + 717 WP_044014559.1 SDR family oxidoreductase -
QI63_RS05470 1226541..1227098 + 558 WP_044014561.1 STAS domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-82)

Antitoxin

Uncharacterised protein family HicB

(52-102)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9624.15 Da        Isoelectric Point: 10.4281

>T48564 WP_081984409.1 NZ_CP009227:c1222421-1222167 [Treponema sp. OMZ 838]
MNSKQKKVYEAIFKNPVQSDIEWQEIENLLHSLGAKISEGNGSRIRIELKGERAVFHRPHPEKVTDKGAIKPMRKFLENA
GIKI

Download         Length: 255 bp

>T48564 NZ_CP009227:c1222421-1222167 [Treponema sp. OMZ 838]
ATGAACTCAAAACAAAAGAAAGTTTATGAGGCTATTTTTAAAAATCCTGTGCAATCAGATATTGAGTGGCAGGAAATAGA
AAATCTTTTACATTCGCTGGGAGCAAAAATATCCGAAGGGAATGGTTCGAGGATCCGTATTGAATTGAAAGGGGAACGTG
CCGTTTTTCATAGGCCGCATCCTGAAAAAGTTACCGATAAAGGTGCAATAAAACCTATGAGAAAATTTTTGGAAAATGCG
GGGATAAAAATATGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12986.68 Da        Isoelectric Point: 4.4898

>AT48564 WP_044014553.1 NZ_CP009227:c1222170-1221829 [Treponema sp. OMZ 838]
MMNYKGFIGVVEYDENARIFSGEVINTRTVITFQGTTVDEIEQEFHASVDDYLEWCKEDGVEPEKPYSGKFNVRISPLFH
SQVAIAAKKMDMSLNSFVEKSLKDEISTMRLTY

Download         Length: 342 bp

>AT48564 NZ_CP009227:c1222170-1221829 [Treponema sp. OMZ 838]
ATGATGAACTATAAAGGATTTATTGGTGTCGTTGAATATGATGAAAATGCTCGTATATTTTCCGGGGAAGTTATAAATAC
TCGTACTGTAATCACATTTCAAGGAACAACAGTAGATGAGATTGAACAGGAATTTCATGCATCTGTTGATGATTATCTTG
AATGGTGTAAGGAAGACGGCGTTGAACCTGAAAAACCTTATTCCGGAAAATTTAATGTTCGTATTTCGCCATTATTTCAT
AGTCAGGTTGCAATTGCAGCAAAGAAAATGGATATGTCATTGAATAGTTTTGTAGAAAAGTCATTAAAAGATGAAATTTC
TACAATGCGATTAACTTATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References