Detailed information of TA system TA048564

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1221829..1222421
• Replicon: chromosome
• Accession: NZ_CP009227
• Organism: Treponema sp. OMZ 838 strain OMZ 838 (ATCC 700772)

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: QI63_RS05445
• Protein ID: WP_081984409.1
• Coordinates: 1222167..1222421 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: QI63_RS05440
• Protein ID: WP_044014553.1
• Coordinates: 1221829..1222170 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QI63_RS05430	1219058..1220890	+	1833	WP_044014551.1	oligoendopeptidase F	-
QI63_RS05435	1220909..1221805	+	897	WP_052185490.1	M28 family peptidase	-
QI63_RS05440	1221829..1222170	-	342	WP_044014553.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
QI63_RS05445	1222167..1222421	-	255	WP_081984409.1	type II toxin-antitoxin system HicA family toxin	Toxin
QI63_RS05450	1222483..1223385	-	903	WP_200877771.1	Fic family protein	-
QI63_RS05455	1223778..1224911	+	1134	WP_044014557.1	sigma-54 dependent transcriptional regulator	-
QI63_RS05460	1224868..1225638	-	771	WP_052185491.1	RNA methyltransferase	-
QI63_RS05465	1225745..1226461	+	717	WP_044014559.1	SDR family oxidoreductase	-
QI63_RS05470	1226541..1227098	+	558	WP_044014561.1	STAS domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-82)

Antitoxin

• Uncharacterised protein family HicB (52-102)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9624.15 Da
• Isoelectric Point: 10.4281

>T48564 WP_081984409.1 NZ_CP009227:c1222421-1222167 [Treponema sp. OMZ 838]
MNSKQKKVYEAIFKNPVQSDIEWQEIENLLHSLGAKISEGNGSRIRIELKGERAVFHRPHPEKVTDKGAIKPMRKFLENA
GIKI

Nucleotide

• Length: 255 bp

>T48564 NZ_CP009227:c1222421-1222167 [Treponema sp. OMZ 838]
ATGAACTCAAAACAAAAGAAAGTTTATGAGGCTATTTTTAAAAATCCTGTGCAATCAGATATTGAGTGGCAGGAAATAGA
AAATCTTTTACATTCGCTGGGAGCAAAAATATCCGAAGGGAATGGTTCGAGGATCCGTATTGAATTGAAAGGGGAACGTG
CCGTTTTTCATAGGCCGCATCCTGAAAAAGTTACCGATAAAGGTGCAATAAAACCTATGAGAAAATTTTTGGAAAATGCG
GGGATAAAAATATGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12986.68 Da
• Isoelectric Point: 4.4898

>AT48564 WP_044014553.1 NZ_CP009227:c1222170-1221829 [Treponema sp. OMZ 838]
MMNYKGFIGVVEYDENARIFSGEVINTRTVITFQGTTVDEIEQEFHASVDDYLEWCKEDGVEPEKPYSGKFNVRISPLFH
SQVAIAAKKMDMSLNSFVEKSLKDEISTMRLTY

Nucleotide

• Length: 342 bp

>AT48564 NZ_CP009227:c1222170-1221829 [Treponema sp. OMZ 838]
ATGATGAACTATAAAGGATTTATTGGTGTCGTTGAATATGATGAAAATGCTCGTATATTTTCCGGGGAAGTTATAAATAC
TCGTACTGTAATCACATTTCAAGGAACAACAGTAGATGAGATTGAACAGGAATTTCATGCATCTGTTGATGATTATCTTG
AATGGTGTAAGGAAGACGGCGTTGAACCTGAAAAACCTTATTCCGGAAAATTTAATGTTCGTATTTCGCCATTATTTCAT
AGTCAGGTTGCAATTGCAGCAAAGAAAATGGATATGTCATTGAATAGTTTTGTAGAAAAGTCATTAAAAGATGAAATTTC
TACAATGCGATTAACTTATTAG