Detailed information of TA system TA048563

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 109291..109870
• Replicon: chromosome
• Accession: NZ_CP009227
• Organism: Treponema sp. OMZ 838 strain OMZ 838 (ATCC 700772)

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: QI63_RS00460
• Protein ID: WP_044012884.1
• Coordinates: 109679..109870 (-)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: QI63_RS00455
• Protein ID: WP_044012882.1
• Coordinates: 109291..109674 (-)
• Length: 128 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QI63_RS00435	104889..105401	-	513	WP_044012867.1	TIGR03546 family protein	-
QI63_RS00440	105805..106491	+	687	WP_044012871.1	outer membrane lipoprotein carrier protein LolA	-
QI63_RS00445	106529..107647	+	1119	WP_044012875.1	helix-turn-helix domain-containing protein	-
QI63_RS00450	107640..109151	+	1512	WP_044012879.1	MiaB/RimO family radical SAM methylthiotransferase	-
QI63_RS00455	109291..109674	-	384	WP_044012882.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
QI63_RS00460	109679..109870	-	192	WP_044012884.1	type II toxin-antitoxin system HicA family toxin	Toxin
QI63_RS00470	110876..112528	+	1653	WP_044012887.1	nucleoside kinase	-
QI63_RS00475	112539..113009	-	471	WP_044012890.1	Cys-tRNA(Pro) deacylase	-
QI63_RS00480	113147..114619	-	1473	WP_044012893.1	glycogen synthase GlgA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-102)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7385.64 Da
• Isoelectric Point: 10.2485

>T48563 WP_044012884.1 NZ_CP009227:c109870-109679 [Treponema sp. OMZ 838]
MNFKEMEKMIKQDGWIKRDIVGSHHHYEHPIKKGKVTIPFHGNKELSKFVVNSILKQAGLKEE

Nucleotide

• Length: 192 bp

>T48563 NZ_CP009227:c109870-109679 [Treponema sp. OMZ 838]
ATGAACTTTAAAGAAATGGAGAAGATGATAAAACAAGACGGATGGATAAAACGTGATATAGTTGGGTCACATCATCACTA
TGAGCATCCGATTAAAAAAGGGAAGGTTACTATTCCATTTCATGGTAACAAGGAGCTTTCGAAGTTTGTAGTAAATAGTA
TTCTTAAACAAGCAGGATTAAAGGAGGAGTAA

Antitoxin

Protein

• Length: 128 a.a.
• Molecular weight: 14303.44 Da
• Isoelectric Point: 4.3514

>AT48563 WP_044012882.1 NZ_CP009227:c109674-109291 [Treponema sp. OMZ 838]
MYIYPAMFYKDENGYSVVFYDIELATMGDTLEEALIMAEEALTGRISLLLKDGETLPNPTAIEDIEKPKDAEFITLVKTD
RKYLAQEKSVRKNLTIPAWLAEAAENAGLNFSQELQCALKTRLHIGI

Nucleotide

• Length: 384 bp

>AT48563 NZ_CP009227:c109674-109291 [Treponema sp. OMZ 838]
ATGTATATTTATCCGGCAATGTTTTATAAAGATGAAAACGGTTATTCGGTTGTATTTTATGATATAGAACTTGCAACGAT
GGGAGACACATTGGAAGAAGCGTTGATAATGGCAGAGGAAGCATTGACAGGACGTATCTCTTTGCTTTTAAAGGATGGAG
AGACACTGCCCAATCCGACAGCTATAGAGGATATAGAAAAACCGAAAGATGCGGAATTTATTACACTGGTAAAAACCGAC
CGTAAATACCTGGCACAGGAAAAAAGTGTTCGTAAAAACTTAACAATTCCTGCATGGCTTGCTGAAGCTGCCGAAAATGC
AGGATTAAATTTTTCGCAAGAGTTGCAATGTGCTCTAAAAACGCGCTTGCATATTGGCATATAA