Detailed information of TA system TA048558

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 1334917..1335473
• Replicon: chromosome
• Accession: NZ_CP009209
• Organism: Burkholderia pseudomallei strain BDP

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: JE55_RS06170
• Protein ID: WP_023594135.1
• Coordinates: 1334917..1335207 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M4UBZ0
• Locus tag: JE55_RS06175
• Protein ID: WP_004541313.1
• Coordinates: 1335195..1335473 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JE55_RS06145	1330401..1330922	+	522	WP_004541357.1	hypothetical protein	-
JE55_RS06150	1331149..1333350	+	2202	WP_004541389.1	AAA family ATPase	-
JE55_RS42200	1333392..1334051	-	660	WP_020850627.1	hypothetical protein	-
JE55_RS40125	1334156..1334404	-	249	WP_004541364.1	hypothetical protein	-
JE55_RS06165	1334600..1334920	-	321	WP_197540451.1	hypothetical protein	-
JE55_RS06170	1334917..1335207	-	291	WP_023594135.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JE55_RS06175	1335195..1335473	-	279	WP_004541313.1	CopG family ribbon-helix-helix protein	Antitoxin
JE55_RS06180	1335554..1337578	-	2025	WP_196043030.1	relaxase/mobilization nuclease domain-containing protein	-
JE55_RS06185	1337581..1337850	-	270	WP_020850841.1	ribbon-helix-helix protein, CopG family	-
JE55_RS33525	1338341..1338598	+	258	WP_004541318.1	hypothetical protein	-
JE55_RS33530	1338676..1339572	+	897	WP_020850700.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1325903..1343051	17148

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10892.45 Da
• Isoelectric Point: 9.5554

>T48558 WP_023594135.1 NZ_CP009209:c1335207-1334917 [Burkholderia pseudomallei]
MPQVIFAPAAIGDMQRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRVDG
DTVTILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T48558 NZ_CP009209:c1335207-1334917 [Burkholderia pseudomallei]
ATGCCACAAGTAATCTTTGCGCCGGCGGCGATCGGGGACATGCAACGGCTCCGCGAATTCCTGAGGCCGAAGAATCCCGA
TGCCGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGTCCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGTCTCATAG
AAGATCTGCCTGAACAGTATCGGGAGTGGCTTATCGATTTTGGGGATAGTGGCTATGTGGCTCGGTACCGCGTCGATGGC
GATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAAGCAGGGTACTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10810.11 Da
• Isoelectric Point: 4.9736

>AT48558 WP_004541313.1 NZ_CP009209:c1335473-1335195 [Burkholderia pseudomallei]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT48558 NZ_CP009209:c1335473-1335195 [Burkholderia pseudomallei]
ATGGTTACGGCAACATCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCCGAGGCGCGCCGGCGTAC
CCCGCACTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGTGAGGAAAAGCGCGAGGCGCTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCACGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCGAGCTGGGGA
ACTGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Structures

Antitoxin

• AlphaFold DB: M4UBZ0