Detailed information of TA system TA048557

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 383733..384774
• Replicon: chromosome
• Accession: NZ_CP009209
• Organism: Burkholderia pseudomallei strain BDP

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: JE55_RS01730
• Protein ID: WP_004539802.1
• Coordinates: 383733..384308 (-)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: A0A0E1SLI7
• Locus tag: JE55_RS01735
• Protein ID: WP_004540053.1
• Coordinates: 384313..384774 (-)
• Length: 154 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JE55_RS01720	379447..379719	-	273	WP_004527347.1	hypothetical protein	-
JE55_RS01725	379903..380082	-	180	WP_004191077.1	hypothetical protein	-
JE55_RS32735	381331..383547	-	2217	WP_004540097.1	ATP-binding protein	-
JE55_RS01730	383733..384308	-	576	WP_004539802.1	PIN domain-containing protein	Toxin
JE55_RS01735	384313..384774	-	462	WP_004540053.1	excisionase family DNA-binding protein	Antitoxin
JE55_RS40000	385427..385825	+	399	WP_133604798.1	hypothetical protein	-
JE55_RS32745	385822..386049	+	228	WP_004540114.1	hypothetical protein	-
JE55_RS40005	386509..386889	+	381	WP_020850431.1	hypothetical protein	-
JE55_RS01745	387287..387712	+	426	WP_004539640.1	PAAR domain-containing protein	-
JE55_RS01750	387709..388215	+	507	WP_004539924.1	DUF4123 domain-containing protein	-
JE55_RS01760	388500..389168	+	669	WP_012730038.1	restriction endonuclease fold toxin 5 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-114)

Antitoxin

• Helix-turn-helix domain, group 17 (83-129)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 22056.35 Da
• Isoelectric Point: 6.4079

>T48557 WP_004539802.1 NZ_CP009209:c384308-383733 [Burkholderia pseudomallei]
MSSNFTVVYDACVLYPAPLRDLLMHLAVTDLYRARWTDMIHDEWTRNLLAKRTDLKPEAIQRTRELMDMHVRDAKVENFE
HLIAAIELPDPDDRHVVAAAMHAGAELIVTMNIKDFPRERVGKYNVSAQHPDDFIVDLWDLNKHKVMEAVARHRKSMKNP
PKSVEDYLDTMANQGLVQTVDALRPYAPWAI

Nucleotide

• Length: 576 bp

>T48557 NZ_CP009209:c384308-383733 [Burkholderia pseudomallei]
ATGTCGTCGAACTTTACCGTTGTCTACGATGCGTGCGTCCTATATCCGGCTCCGTTGCGCGACTTGTTGATGCATCTCGC
GGTGACGGATCTGTACCGCGCGCGTTGGACCGATATGATTCATGACGAGTGGACAAGGAATTTGCTCGCGAAGCGAACCG
ACCTGAAACCCGAGGCGATCCAGCGCACGCGGGAACTGATGGACATGCATGTTCGCGACGCGAAAGTGGAAAACTTCGAG
CATCTGATTGCGGCGATCGAGTTGCCCGATCCTGATGATCGTCATGTCGTCGCGGCAGCCATGCATGCTGGGGCGGAACT
CATCGTCACGATGAACATCAAGGATTTCCCGAGGGAGCGGGTCGGAAAGTACAACGTGTCGGCTCAACATCCCGACGATT
TCATCGTCGACTTGTGGGACTTGAACAAGCACAAGGTGATGGAGGCGGTCGCGCGACATCGCAAGTCGATGAAGAACCCG
CCGAAGTCAGTGGAAGACTATCTCGACACGATGGCCAATCAGGGACTCGTGCAGACGGTCGATGCGCTGCGGCCGTATGC
GCCTTGGGCTATCTGA

Antitoxin

Protein

• Length: 154 a.a.
• Molecular weight: 17155.41 Da
• Isoelectric Point: 5.5474

>AT48557 WP_004540053.1 NZ_CP009209:c384774-384313 [Burkholderia pseudomallei]
MNTTVTPAALPSEHEAELARESRRNLVTVVNSHAETQQFDFKDEKGETHTVTLPTSALRLLDEILHQIGNGNAVSIIPIH
AELTTQQAADLLNVSRPYLVQLLEQGEIPFRKVNTHRRVMYLDLIQYKNKIDANRLDALAELTAQAQELGMGY

Nucleotide

• Length: 462 bp

>AT48557 NZ_CP009209:c384774-384313 [Burkholderia pseudomallei]
ATGAACACCACTGTCACTCCTGCGGCCCTCCCGTCCGAACACGAGGCCGAGCTCGCGCGCGAGTCGCGGCGGAATTTGGT
CACGGTCGTGAACAGCCACGCCGAGACTCAGCAGTTTGATTTCAAGGACGAAAAGGGGGAGACGCATACAGTCACGCTTC
CGACCTCGGCGTTAAGGCTGCTAGACGAGATCCTCCATCAGATCGGAAATGGCAACGCGGTGTCGATCATTCCAATCCAT
GCCGAATTGACGACCCAGCAAGCCGCCGACCTTCTGAATGTCTCGCGTCCGTACCTGGTTCAACTTCTTGAGCAGGGAGA
GATCCCATTCCGGAAGGTAAATACGCATCGACGGGTGATGTATCTGGATCTGATTCAGTACAAAAACAAGATCGATGCGA
ACCGTCTCGACGCGCTGGCTGAACTGACGGCTCAGGCGCAGGAACTTGGAATGGGATATTGA

Structures

Antitoxin

• AlphaFold DB: A0A0E1SLI7