Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1829652..1830280 Replicon chromosome
Accession NZ_CP009170
Organism Thermoanaerobacter kivui strain LKT-1

Toxin (Protein)


Gene name mazF Uniprot ID B0KD57
Locus tag TKV_RS09185 Protein ID WP_003867472.1
Coordinates 1829652..1830002 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M8DD10
Locus tag TKV_RS09190 Protein ID WP_003870023.1
Coordinates 1830005..1830280 (-) Length 92 a.a.

Genomic Context

TKV_RS09165TKV_RS09170TKV_RS09175TKV_RS09180TKV_RS09185TKV_RS09190TKV_RS09195TKV_RS09200TKV_RS09205TKV_RS09210TKV_RS09215
Location: 1825142..1825879 (738 bp)
Type: Others
Protein ID: WP_049685679.1
Location: 1825882..1826973 (1092 bp)
Type: Others
Protein ID: WP_049685680.1
Location: 1826975..1828987 (2013 bp)
Type: Others
Protein ID: WP_049685681.1
Location: 1829102..1829554 (453 bp)
Type: Others
Protein ID: WP_049685682.1
Location: 1829652..1830002 (351 bp)
Type: Toxin
Protein ID: WP_003867472.1
Location: 1830005..1830280 (276 bp)
Type: Antitoxin
Protein ID: WP_003870023.1
Location: 1830370..1831536 (1167 bp)
Type: Others
Protein ID: WP_049686269.1
Location: 1831556..1832587 (1032 bp)
Type: Others
Protein ID: WP_049685683.1
Location: 1832575..1834107 (1533 bp)
Type: Others
Protein ID: WP_049685684.1
Location: 1834070..1834486 (417 bp)
Type: Others
Protein ID: WP_049685685.1
Location: 1834585..1834950 (366 bp)
Type: Others
Protein ID: WP_049685686.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
TKV_RS091651825142..1825879-738WP_049685679.1WecB/TagA/CpsF family glycosyltransferase-
TKV_RS091701825882..1826973-1092WP_049685680.1polysaccharide pyruvyl transferase CsaB-
TKV_RS091751826975..1828987-2013WP_049685681.1hypothetical protein-
TKV_RS091801829102..1829554-453WP_049685682.1hypothetical protein-
TKV_RS091851829652..1830002-351WP_003867472.1type II toxin-antitoxin system PemK/MazF family toxinToxin
TKV_RS091901830005..1830280-276WP_003870023.1ribbon-helix-helix protein, CopG familyAntitoxin
TKV_RS091951830370..1831536-1167WP_049686269.1alanine racemase-
TKV_RS092001831556..1832587-1032WP_049685683.1outer membrane lipoprotein carrier protein LolA-
TKV_RS092051832575..1834107-1533WP_049685684.1bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase-
TKV_RS092101834070..1834486-417WP_049685685.1holo-ACP synthase-
TKV_RS092151834585..1834950-366WP_049685686.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1829652..184314913497


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12933.02 Da        Isoelectric Point: 6.4714

>T48537 WP_003867472.1 NZ_CP009170:c1830002-1829652 [Thermoanaerobacter kivui]
MVIKRGDIFYADLSPVIGSEQGGIRPVLIIQNDIGNKYSPTVIVAAITSQINKAKLPTHVEINGAEYGLNKDSVVLLEQI
RTIDKKRLREKIGHFDQEMMEKVNEALQISLGLIDF

Download         Length: 351 bp

>T48537 NZ_CP009170:c1830002-1829652 [Thermoanaerobacter kivui]
ATGGTGATAAAGAGAGGAGATATCTTTTATGCCGATTTAAGCCCTGTAATAGGCTCTGAACAGGGTGGAATTCGGCCTGT
ACTTATAATTCAAAATGATATTGGTAATAAATATAGTCCAACAGTAATAGTAGCGGCAATTACATCTCAGATCAACAAAG
CCAAATTGCCCACTCATGTTGAAATAAATGGGGCAGAATATGGACTTAACAAAGATTCTGTAGTATTGTTAGAACAAATC
AGGACTATCGACAAAAAACGTTTAAGAGAAAAAATTGGCCATTTTGACCAGGAAATGATGGAGAAAGTCAATGAAGCTTT
GCAAATAAGTTTAGGGTTGATTGATTTTTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10547.32 Da        Isoelectric Point: 6.3662

>AT48537 WP_003870023.1 NZ_CP009170:c1830280-1830005 [Thermoanaerobacter kivui]
VGETKRILVSLPQSLLEEVDVLAAMENRNRSEFIREAMKLYIRERKKVQIRESMKKGYLEMAAINSELAEMGLTAENECF
TGYEMKLKKCD

Download         Length: 276 bp

>AT48537 NZ_CP009170:c1830280-1830005 [Thermoanaerobacter kivui]
GTGGGCGAAACAAAGCGAATACTTGTAAGCTTACCTCAGAGTTTATTAGAAGAGGTCGATGTTCTTGCCGCTATGGAAAA
CAGAAATCGCAGTGAATTTATAAGAGAAGCGATGAAATTATATATACGCGAGAGGAAAAAAGTTCAAATACGCGAGAGCA
TGAAAAAAGGATATCTCGAGATGGCAGCAATTAATAGTGAACTTGCGGAAATGGGCCTAACCGCAGAAAATGAATGTTTT
ACAGGATATGAAATGAAATTGAAAAAGTGTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0B3BRL3

Antitoxin

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Source
ID
Structure
AlphaFold DBM8DD10

References