Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4114450..4115251 | Replicon | chromosome |
| Accession | NZ_CP009166 | ||
| Organism | Escherichia coli 1303 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A3W5RL53 |
| Locus tag | EC1303_RS20155 | Protein ID | WP_041124173.1 |
| Coordinates | 4114874..4115251 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A3W5RLB4 |
| Locus tag | EC1303_RS20150 | Protein ID | WP_041124172.1 |
| Coordinates | 4114450..4114827 (+) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EC1303_RS20115 | 4110351..4111031 | + | 681 | WP_001282912.1 | WYL domain-containing protein | - |
| EC1303_RS20120 | 4111182..4111859 | + | 678 | WP_021559490.1 | hypothetical protein | - |
| EC1303_RS20125 | 4111865..4112098 | + | 234 | WP_001278287.1 | DUF905 family protein | - |
| EC1303_RS20130 | 4112197..4113015 | + | 819 | WP_041124169.1 | DUF945 domain-containing protein | - |
| EC1303_RS20135 | 4113107..4113592 | + | 486 | WP_041124170.1 | antirestriction protein | - |
| EC1303_RS20140 | 4113608..4114084 | + | 477 | WP_041124171.1 | RadC family protein | - |
| EC1303_RS20145 | 4114153..4114374 | + | 222 | WP_000692307.1 | DUF987 domain-containing protein | - |
| EC1303_RS20150 | 4114450..4114827 | + | 378 | WP_041124172.1 | type IV toxin-antitoxin system toxin CbtA | Antitoxin |
| EC1303_RS20155 | 4114874..4115251 | + | 378 | WP_041124173.1 | TA system toxin CbtA family protein | Toxin |
| EC1303_RS20160 | 4115248..4115736 | + | 489 | WP_041124174.1 | hypothetical protein | - |
| EC1303_RS20165 | 4115748..4115945 | + | 198 | WP_000839249.1 | DUF957 domain-containing protein | - |
| EC1303_RS20170 | 4116030..4116872 | + | 843 | WP_041124175.1 | DUF4942 domain-containing protein | - |
| EC1303_RS20180 | 4117666..4118850 | + | 1185 | WP_001172876.1 | sugar efflux transporter | - |
| EC1303_RS20185 | 4118961..4119884 | + | 924 | WP_000535961.1 | carboxylate/amino acid/amine transporter | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13991.90 Da Isoelectric Point: 7.3225
>T48528 WP_041124173.1 NZ_CP009166:4114874-4115251 [Escherichia coli 1303]
MNTLPDTHVRETSGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRSHYRTVNDITLGKRTEAKR
MNTLPDTHVRETSGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRSHYRTVNDITLGKRTEAKR
Download Length: 378 bp
>T48528 NZ_CP009166:4114874-4115251 [Escherichia coli 1303]
ATGAATACATTACCCGACACTCACGTACGGGAGACATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CCACTACAGAACGGTAAATGACATTACCCTGGGTAAACGTACGGAGGCAAAACGATGA
ATGAATACATTACCCGACACTCACGTACGGGAGACATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CCACTACAGAACGGTAAATGACATTACCCTGGGTAAACGTACGGAGGCAAAACGATGA
Antitoxin
Download Length: 126 a.a. Molecular weight: 13752.57 Da Isoelectric Point: 6.2021
>AT48528 WP_041124172.1 NZ_CP009166:4114450-4114827 [Escherichia coli 1303]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRASIRGRFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRASIRGRFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
Download Length: 378 bp
>AT48528 NZ_CP009166:4114450-4114827 [Escherichia coli 1303]
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCCGACTGGTACAGGAGGGTAACCGCCTGCATTACCTTGCAGACCGCGCCAGTATCAGAGGCAGGT
TCAGCGACGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCGGCGGT
GAACTGAATCCCCGTCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGTATAA
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCCGACTGGTACAGGAGGGTAACCGCCTGCATTACCTTGCAGACCGCGCCAGTATCAGAGGCAGGT
TCAGCGACGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCGGCGGT
GAACTGAATCCCCGTCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3W5RL53 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3W5RLB4 |