Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2288235..2289066 Replicon chromosome
Accession NZ_CP009166
Organism Escherichia coli 1303

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag EC1303_RS11390 Protein ID WP_000854814.1
Coordinates 2288692..2289066 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag EC1303_RS11385 Protein ID WP_001285585.1
Coordinates 2288235..2288603 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC1303_RS11350 2283466..2284536 + 1071 WP_041124115.1 patatin-like phospholipase family protein -
EC1303_RS11355 2284868..2285356 + 489 WP_000825476.1 hypothetical protein -
EC1303_RS11360 2285372..2285782 + 411 WP_000846713.1 hypothetical protein -
EC1303_RS11365 2286003..2286824 + 822 WP_024198033.1 DUF945 domain-containing protein -
EC1303_RS11370 2286906..2287385 + 480 WP_000860076.1 antirestriction protein -
EC1303_RS11375 2287401..2287877 + 477 WP_001186773.1 RadC family protein -
EC1303_RS11380 2287940..2288161 + 222 WP_000692323.1 DUF987 domain-containing protein -
EC1303_RS11385 2288235..2288603 + 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
EC1303_RS11390 2288692..2289066 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
EC1303_RS11395 2289063..2289257 + 195 WP_001752758.1 hypothetical protein -
EC1303_RS29225 2289270..2289383 + 114 WP_001161660.1 DUF957 domain-containing protein -
EC1303_RS26705 2289672..2289800 - 129 Protein_2168 transposase domain-containing protein -
EC1303_RS11405 2289872..2290054 + 183 WP_001016348.1 hypothetical protein -
EC1303_RS11410 2290155..2290484 - 330 WP_000450409.1 DUF496 family protein -
EC1303_RS11415 2290656..2291714 - 1059 WP_001200891.1 FUSC family protein -
EC1303_RS11420 2291912..2292385 - 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
EC1303_RS11425 2292504..2293670 - 1167 WP_024198034.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T48522 WP_000854814.1 NZ_CP009166:2288692-2289066 [Escherichia coli 1303]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T48522 NZ_CP009166:2288692-2289066 [Escherichia coli 1303]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT48522 WP_001285585.1 NZ_CP009166:2288235-2288603 [Escherichia coli 1303]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT48522 NZ_CP009166:2288235-2288603 [Escherichia coli 1303]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References