Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1121535..1122190 Replicon chromosome
Accession NZ_CP009165
Organism Burkholderia pseudomallei A79A

Toxin (Protein)


Gene name relE Uniprot ID A0A0H2WL39
Locus tag X996_RS18510 Protein ID WP_004199884.1
Coordinates 1121894..1122190 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag X996_RS18505 Protein ID WP_004202809.1
Coordinates 1121535..1121891 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
X996_RS18475 1117669..1118427 + 759 WP_004521940.1 cytochrome c1 -
X996_RS18480 1118520..1119131 + 612 WP_004185176.1 glutathione S-transferase N-terminal domain-containing protein -
X996_RS18485 1119201..1119722 + 522 WP_004527881.1 ClpXP protease specificity-enhancing factor -
X996_RS18495 1119944..1120439 + 496 Protein_1007 terminase -
X996_RS18500 1120436..1121491 + 1056 WP_038724553.1 phage portal protein -
X996_RS18505 1121535..1121891 - 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
X996_RS18510 1121894..1122190 - 297 WP_004199884.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
X996_RS36165 1122858..1124114 + 1257 WP_004552667.1 AAA family ATPase -
X996_RS18520 1124159..1124734 + 576 WP_198014201.1 DUF4276 family protein -
X996_RS18525 1125507..1125833 + 327 WP_038759954.1 baseplate assembly protein -
X996_RS18530 1125826..1126237 + 412 Protein_1014 phage tail protein I -
X996_RS18535 1126322..1126738 + 417 WP_076926800.1 DNA methylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1120125..1128190 8065


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(8-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10840.66 Da        Isoelectric Point: 10.1723

>T48505 WP_004199884.1 NZ_CP009165:c1122190-1121894 [Burkholderia pseudomallei A79A]
MFKVLTPPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T48505 NZ_CP009165:c1122190-1121894 [Burkholderia pseudomallei A79A]
ATGTTCAAAGTTCTGACGCCCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCGTGCGACGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT48505 WP_004202809.1 NZ_CP009165:c1121891-1121535 [Burkholderia pseudomallei A79A]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT48505 NZ_CP009165:c1121891-1121535 [Burkholderia pseudomallei A79A]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGGAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAGGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTCGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2WL39

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References