Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 2500470..2501511 | Replicon | chromosome |
| Accession | NZ_CP009161 | ||
| Organism | Burkholderia pseudomallei TSV 48 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | X988_RS24085 | Protein ID | WP_038714125.1 |
| Coordinates | 2500470..2501045 (-) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | A0A0E1SLI7 |
| Locus tag | X988_RS24090 | Protein ID | WP_004540053.1 |
| Coordinates | 2501050..2501511 (-) | Length | 154 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| X988_RS24065 | 2496176..2496448 | - | 273 | WP_004527347.1 | hypothetical protein | - |
| X988_RS24070 | 2496632..2496811 | - | 180 | WP_004191077.1 | hypothetical protein | - |
| X988_RS37725 | 2497646..2497885 | + | 240 | WP_076900745.1 | DNA mismatch repair protein | - |
| X988_RS24075 | 2498191..2499075 | + | 885 | WP_038764874.1 | hypothetical protein | - |
| X988_RS24080 | 2499161..2499937 | + | 777 | WP_128972300.1 | hypothetical protein | - |
| X988_RS40085 | 2500191..2500454 | - | 264 | WP_128972301.1 | hypothetical protein | - |
| X988_RS24085 | 2500470..2501045 | - | 576 | WP_038714125.1 | PIN domain-containing protein | Toxin |
| X988_RS24090 | 2501050..2501511 | - | 462 | WP_004540053.1 | excisionase family DNA-binding protein | Antitoxin |
| X988_RS40095 | 2503007..2504146 | - | 1140 | WP_128972302.1 | hypothetical protein | - |
| X988_RS40100 | 2504707..2505087 | + | 381 | WP_128972303.1 | hypothetical protein | - |
| X988_RS24100 | 2505485..2505907 | + | 423 | WP_009937903.1 | PAAR domain-containing protein | - |
| X988_RS24105 | 2505904..2506410 | + | 507 | WP_082248464.1 | DUF4123 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 22057.42 Da Isoelectric Point: 6.4079
>T48497 WP_038714125.1 NZ_CP009161:c2501045-2500470 [Burkholderia pseudomallei TSV 48]
MSSNFTVVYDACVLYPAPLRDLLMHLALTDLYRARWTDMIHDEWTRNLLAKRTDLKPEAIQRTRELMDMHVRDAKVENFE
HLIAVIELPDPDDRHVVAAAMHAGAELIVTMNIKDFPKERVAKYNVSAQHPDDFIVDLWDLNKHKVMEAVARHRKSMKNP
PKSVEDYLDTMASQGLVQTVDALRPYAPWAI
MSSNFTVVYDACVLYPAPLRDLLMHLALTDLYRARWTDMIHDEWTRNLLAKRTDLKPEAIQRTRELMDMHVRDAKVENFE
HLIAVIELPDPDDRHVVAAAMHAGAELIVTMNIKDFPKERVAKYNVSAQHPDDFIVDLWDLNKHKVMEAVARHRKSMKNP
PKSVEDYLDTMASQGLVQTVDALRPYAPWAI
Download Length: 576 bp
>T48497 NZ_CP009161:c2501045-2500470 [Burkholderia pseudomallei TSV 48]
ATGTCGTCGAACTTTACCGTTGTCTACGATGCGTGCGTCCTATATCCGGCTCCGTTGCGAGACCTGCTGATGCACCTCGC
GCTGACGGACCTGTACCGCGCGCGTTGGACCGATATGATTCATGACGAGTGGACGAGGAATTTGCTCGCGAAGCGAACCG
ACCTGAAACCCGAGGCGATCCAGCGCACGCGGGAACTCATGGACATGCATGTTCGCGACGCGAAAGTTGAAAACTTCGAG
CATTTGATCGCGGTGATCGAGTTGCCCGACCCTGACGACCGTCATGTCGTCGCTGCGGCCATGCATGCTGGGGCAGAGCT
CATCGTCACGATGAACATCAAGGATTTCCCGAAGGAGCGGGTCGCAAAGTACAACGTGTCGGCGCAACATCCCGACGATT
TCATCGTCGACTTGTGGGACTTGAACAAGCACAAGGTGATGGAGGCGGTCGCGCGACATCGCAAGTCGATGAAGAATCCG
CCGAAATCAGTGGAAGACTATCTCGACACGATGGCCAGCCAGGGACTCGTGCAGACGGTTGATGCGCTGCGGCCGTATGC
GCCTTGGGCTATCTGA
ATGTCGTCGAACTTTACCGTTGTCTACGATGCGTGCGTCCTATATCCGGCTCCGTTGCGAGACCTGCTGATGCACCTCGC
GCTGACGGACCTGTACCGCGCGCGTTGGACCGATATGATTCATGACGAGTGGACGAGGAATTTGCTCGCGAAGCGAACCG
ACCTGAAACCCGAGGCGATCCAGCGCACGCGGGAACTCATGGACATGCATGTTCGCGACGCGAAAGTTGAAAACTTCGAG
CATTTGATCGCGGTGATCGAGTTGCCCGACCCTGACGACCGTCATGTCGTCGCTGCGGCCATGCATGCTGGGGCAGAGCT
CATCGTCACGATGAACATCAAGGATTTCCCGAAGGAGCGGGTCGCAAAGTACAACGTGTCGGCGCAACATCCCGACGATT
TCATCGTCGACTTGTGGGACTTGAACAAGCACAAGGTGATGGAGGCGGTCGCGCGACATCGCAAGTCGATGAAGAATCCG
CCGAAATCAGTGGAAGACTATCTCGACACGATGGCCAGCCAGGGACTCGTGCAGACGGTTGATGCGCTGCGGCCGTATGC
GCCTTGGGCTATCTGA
Antitoxin
Download Length: 154 a.a. Molecular weight: 17155.41 Da Isoelectric Point: 5.5474
>AT48497 WP_004540053.1 NZ_CP009161:c2501511-2501050 [Burkholderia pseudomallei TSV 48]
MNTTVTPAALPSEHEAELARESRRNLVTVVNSHAETQQFDFKDEKGETHTVTLPTSALRLLDEILHQIGNGNAVSIIPIH
AELTTQQAADLLNVSRPYLVQLLEQGEIPFRKVNTHRRVMYLDLIQYKNKIDANRLDALAELTAQAQELGMGY
MNTTVTPAALPSEHEAELARESRRNLVTVVNSHAETQQFDFKDEKGETHTVTLPTSALRLLDEILHQIGNGNAVSIIPIH
AELTTQQAADLLNVSRPYLVQLLEQGEIPFRKVNTHRRVMYLDLIQYKNKIDANRLDALAELTAQAQELGMGY
Download Length: 462 bp
>AT48497 NZ_CP009161:c2501511-2501050 [Burkholderia pseudomallei TSV 48]
ATGAACACCACTGTCACTCCTGCGGCCCTCCCGTCCGAACACGAGGCCGAGCTCGCGCGCGAGTCGCGGCGGAATTTGGT
CACGGTCGTGAACAGCCACGCCGAGACTCAGCAGTTTGATTTCAAGGACGAAAAGGGGGAGACGCATACAGTCACGCTTC
CGACCTCGGCGTTAAGGCTGCTAGACGAGATCCTCCATCAGATCGGAAATGGCAACGCGGTGTCGATCATTCCAATCCAT
GCCGAATTGACGACCCAGCAAGCCGCCGACCTTCTGAATGTCTCGCGTCCGTACCTGGTTCAACTTCTTGAGCAGGGAGA
GATCCCATTCCGGAAGGTAAATACGCATCGACGGGTGATGTATCTGGATCTGATTCAGTACAAAAACAAGATCGATGCGA
ACCGTCTCGACGCGCTGGCTGAACTGACGGCTCAGGCGCAGGAACTTGGAATGGGATATTGA
ATGAACACCACTGTCACTCCTGCGGCCCTCCCGTCCGAACACGAGGCCGAGCTCGCGCGCGAGTCGCGGCGGAATTTGGT
CACGGTCGTGAACAGCCACGCCGAGACTCAGCAGTTTGATTTCAAGGACGAAAAGGGGGAGACGCATACAGTCACGCTTC
CGACCTCGGCGTTAAGGCTGCTAGACGAGATCCTCCATCAGATCGGAAATGGCAACGCGGTGTCGATCATTCCAATCCAT
GCCGAATTGACGACCCAGCAAGCCGCCGACCTTCTGAATGTCTCGCGTCCGTACCTGGTTCAACTTCTTGAGCAGGGAGA
GATCCCATTCCGGAAGGTAAATACGCATCGACGGGTGATGTATCTGGATCTGATTCAGTACAAAAACAAGATCGATGCGA
ACCGTCTCGACGCGCTGGCTGAACTGACGGCTCAGGCGCAGGAACTTGGAATGGGATATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|