Detailed information of TA system TA048497

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 2500470..2501511
• Replicon: chromosome
• Accession: NZ_CP009161
• Organism: Burkholderia pseudomallei TSV 48

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: X988_RS24085
• Protein ID: WP_038714125.1
• Coordinates: 2500470..2501045 (-)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: A0A0E1SLI7
• Locus tag: X988_RS24090
• Protein ID: WP_004540053.1
• Coordinates: 2501050..2501511 (-)
• Length: 154 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
X988_RS24065	2496176..2496448	-	273	WP_004527347.1	hypothetical protein	-
X988_RS24070	2496632..2496811	-	180	WP_004191077.1	hypothetical protein	-
X988_RS37725	2497646..2497885	+	240	WP_076900745.1	DNA mismatch repair protein	-
X988_RS24075	2498191..2499075	+	885	WP_038764874.1	hypothetical protein	-
X988_RS24080	2499161..2499937	+	777	WP_128972300.1	hypothetical protein	-
X988_RS40085	2500191..2500454	-	264	WP_128972301.1	hypothetical protein	-
X988_RS24085	2500470..2501045	-	576	WP_038714125.1	PIN domain-containing protein	Toxin
X988_RS24090	2501050..2501511	-	462	WP_004540053.1	excisionase family DNA-binding protein	Antitoxin
X988_RS40095	2503007..2504146	-	1140	WP_128972302.1	hypothetical protein	-
X988_RS40100	2504707..2505087	+	381	WP_128972303.1	hypothetical protein	-
X988_RS24100	2505485..2505907	+	423	WP_009937903.1	PAAR domain-containing protein	-
X988_RS24105	2505904..2506410	+	507	WP_082248464.1	DUF4123 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-114)

Antitoxin

• Helix-turn-helix domain, group 17 (83-129)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 22057.42 Da
• Isoelectric Point: 6.4079

>T48497 WP_038714125.1 NZ_CP009161:c2501045-2500470 [Burkholderia pseudomallei TSV 48]
MSSNFTVVYDACVLYPAPLRDLLMHLALTDLYRARWTDMIHDEWTRNLLAKRTDLKPEAIQRTRELMDMHVRDAKVENFE
HLIAVIELPDPDDRHVVAAAMHAGAELIVTMNIKDFPKERVAKYNVSAQHPDDFIVDLWDLNKHKVMEAVARHRKSMKNP
PKSVEDYLDTMASQGLVQTVDALRPYAPWAI

Nucleotide

• Length: 576 bp

>T48497 NZ_CP009161:c2501045-2500470 [Burkholderia pseudomallei TSV 48]
ATGTCGTCGAACTTTACCGTTGTCTACGATGCGTGCGTCCTATATCCGGCTCCGTTGCGAGACCTGCTGATGCACCTCGC
GCTGACGGACCTGTACCGCGCGCGTTGGACCGATATGATTCATGACGAGTGGACGAGGAATTTGCTCGCGAAGCGAACCG
ACCTGAAACCCGAGGCGATCCAGCGCACGCGGGAACTCATGGACATGCATGTTCGCGACGCGAAAGTTGAAAACTTCGAG
CATTTGATCGCGGTGATCGAGTTGCCCGACCCTGACGACCGTCATGTCGTCGCTGCGGCCATGCATGCTGGGGCAGAGCT
CATCGTCACGATGAACATCAAGGATTTCCCGAAGGAGCGGGTCGCAAAGTACAACGTGTCGGCGCAACATCCCGACGATT
TCATCGTCGACTTGTGGGACTTGAACAAGCACAAGGTGATGGAGGCGGTCGCGCGACATCGCAAGTCGATGAAGAATCCG
CCGAAATCAGTGGAAGACTATCTCGACACGATGGCCAGCCAGGGACTCGTGCAGACGGTTGATGCGCTGCGGCCGTATGC
GCCTTGGGCTATCTGA

Antitoxin

Protein

• Length: 154 a.a.
• Molecular weight: 17155.41 Da
• Isoelectric Point: 5.5474

>AT48497 WP_004540053.1 NZ_CP009161:c2501511-2501050 [Burkholderia pseudomallei TSV 48]
MNTTVTPAALPSEHEAELARESRRNLVTVVNSHAETQQFDFKDEKGETHTVTLPTSALRLLDEILHQIGNGNAVSIIPIH
AELTTQQAADLLNVSRPYLVQLLEQGEIPFRKVNTHRRVMYLDLIQYKNKIDANRLDALAELTAQAQELGMGY

Nucleotide

• Length: 462 bp

>AT48497 NZ_CP009161:c2501511-2501050 [Burkholderia pseudomallei TSV 48]
ATGAACACCACTGTCACTCCTGCGGCCCTCCCGTCCGAACACGAGGCCGAGCTCGCGCGCGAGTCGCGGCGGAATTTGGT
CACGGTCGTGAACAGCCACGCCGAGACTCAGCAGTTTGATTTCAAGGACGAAAAGGGGGAGACGCATACAGTCACGCTTC
CGACCTCGGCGTTAAGGCTGCTAGACGAGATCCTCCATCAGATCGGAAATGGCAACGCGGTGTCGATCATTCCAATCCAT
GCCGAATTGACGACCCAGCAAGCCGCCGACCTTCTGAATGTCTCGCGTCCGTACCTGGTTCAACTTCTTGAGCAGGGAGA
GATCCCATTCCGGAAGGTAAATACGCATCGACGGGTGATGTATCTGGATCTGATTCAGTACAAAAACAAGATCGATGCGA
ACCGTCTCGACGCGCTGGCTGAACTGACGGCTCAGGCGCAGGAACTTGGAATGGGATATTGA

Structures

Antitoxin

• AlphaFold DB: A0A0E1SLI7