48495

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2412767..2413422 Replicon chromosome
Accession NZ_CP009160
Organism Burkholderia pseudomallei TSV 48

Toxin (Protein)


Gene name relE Uniprot ID A0A0F6LEW6
Locus tag X988_RS09820 Protein ID WP_006027262.1
Coordinates 2413126..2413422 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag X988_RS09815 Protein ID WP_004202809.1
Coordinates 2412767..2413123 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
X988_RS09795 2407901..2408914 - 1014 WP_038765886.1 phage major capsid protein, P2 family -
X988_RS09800 2408948..2409757 - 810 WP_038765884.1 GPO family capsid scaffolding protein -
X988_RS09805 2409901..2411670 + 1770 WP_038765882.1 terminase ATPase subunit family protein -
X988_RS09810 2411667..2412722 + 1056 WP_038796190.1 phage portal protein -
X988_RS09815 2412767..2413123 - 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
X988_RS09820 2413126..2413422 - 297 WP_006027262.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
X988_RS34565 2414053..2414766 - 714 WP_080002914.1 cellulose biosynthesis protein BcsS -
X988_RS09825 2414693..2416942 - 2250 WP_009979045.1 glycosyltransferase -
X988_RS09830 2417053..2418417 - 1365 WP_051781513.1 GGDEF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2388728..2428408 39680


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10844.65 Da        Isoelectric Point: 10.1723

>T48495 WP_006027262.1 NZ_CP009160:c2413422-2413126 [Burkholderia pseudomallei TSV 48]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T48495 NZ_CP009160:c2413422-2413126 [Burkholderia pseudomallei TSV 48]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTATTTCGTGCGGCGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT48495 WP_004202809.1 NZ_CP009160:c2413123-2412767 [Burkholderia pseudomallei TSV 48]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT48495 NZ_CP009160:c2413123-2412767 [Burkholderia pseudomallei TSV 48]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGGAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTCGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6LEW6

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References