Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2073331..2074880 Replicon chromosome
Accession NZ_CP009158
Organism Glaesserella parasuis strain SH03

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JL26_RS10325 Protein ID WP_038514996.1
Coordinates 2073564..2074880 (+) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID U4SAZ6
Locus tag JL26_RS10320 Protein ID WP_010786623.1
Coordinates 2073331..2073570 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL26_RS10295 2069157..2069411 + 255 WP_005713300.1 alpha/beta hydrolase -
JL26_RS10300 2069537..2070115 - 579 WP_020457616.1 transcription termination/antitermination protein NusG -
JL26_RS10305 2070117..2070527 - 411 WP_021114216.1 preprotein translocase subunit SecE -
JL26_RS10310 2070780..2072225 - 1446 WP_038514994.1 metalloprotease TldD -
JL26_RS10315 2072356..2073183 + 828 WP_005713289.1 alpha/beta hydrolase -
JL26_RS10320 2073331..2073570 + 240 WP_010786623.1 helix-turn-helix domain-containing protein Antitoxin
JL26_RS10325 2073564..2074880 + 1317 WP_038514996.1 type II toxin-antitoxin system HipA family toxin Toxin
JL26_RS10330 2074884..2076425 - 1542 WP_198351646.1 PLP-dependent aminotransferase family protein -
JL26_RS10335 2076449..2076964 - 516 WP_080697476.1 hypothetical protein -
JL26_RS10340 2076864..2077223 + 360 WP_010787368.1 hypothetical protein -
JL26_RS10345 2077410..2077983 + 574 Protein_2035 virulence RhuM family protein -
JL26_RS11925 2078064..2078180 - 117 Protein_2036 LysR family transcriptional regulator -
JL26_RS10350 2078315..2078758 + 444 WP_038515000.1 nuclear transport factor 2 family protein -
JL26_RS10355 2078758..2078937 + 180 Protein_2038 disulfide bond formation protein DsbA -
JL26_RS10360 2079202..2079789 - 588 WP_026916625.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-104)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-66)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49987.24 Da        Isoelectric Point: 7.6047

>T48485 WP_038514996.1 NZ_CP009158:2073564-2074880 [Glaesserella parasuis]
MVMRLRVLMNGEMVGYFDRTLSGSHHFTYAESWLNSPLARPISLSMPLQRATYQGKEVINFFDNLLPDNPQIRARIATRF
NAETQQPFDLLAKIGRDAAGAITLLGEDEQIPNHRIIQATELNESEMAKILQSYQYNAPLGMIDNNQDFRISIAGAQEKT
ALLWHNSKWKLPHGLTPTTHIFKLPMGEIRTPKHLLDLSKSVDNELVCLRLFSAFNIPSANVELLEMNDIRALAVERFDR
RLSQDGSYFLRLPYEDFCQAFGLSPTQKYESDGGIGIGDMMNKLLYSSNSNDRRQFMQTQFLFWLLAAIDGHAKNFSLAI
EKQGRYHLSPVYDVLSAYPMLGGKGWHHSELQMAMSLRSTQKGKKWHWSKIYAEHFYATAKFVGFSSSDMKQVIEQICDT
VQETIDSVATTLPKQIDENVRDQIFTGIMKQVQKVSMK

Download         Length: 1317 bp

>T48485 NZ_CP009158:2073564-2074880 [Glaesserella parasuis]
ATGGTAATGCGATTACGAGTATTAATGAATGGCGAAATGGTTGGGTATTTTGACCGCACTTTATCGGGTTCCCACCATTT
TACCTATGCTGAAAGTTGGCTAAATTCCCCATTAGCTCGCCCGATTTCCCTTTCTATGCCCCTGCAAAGAGCAACATATC
AAGGCAAAGAAGTGATTAATTTCTTTGATAATTTACTGCCCGATAATCCTCAAATTCGAGCAAGAATTGCGACAAGATTT
AATGCTGAAACACAACAACCTTTTGACTTACTTGCTAAAATTGGTCGCGATGCTGCGGGTGCTATTACTCTTTTAGGGGA
AGATGAACAAATTCCTAATCATCGAATAATTCAAGCCACAGAATTAAACGAGAGTGAAATGGCGAAAATTCTACAAAGTT
ATCAATACAATGCCCCGCTTGGTATGATTGATAATAATCAGGACTTCAGAATTTCTATTGCTGGTGCACAAGAAAAAACA
GCTCTGCTTTGGCATAACAGCAAATGGAAATTACCACACGGATTGACCCCGACAACGCATATTTTCAAATTGCCTATGGG
AGAAATTCGCACCCCTAAACACCTGCTTGATCTGTCAAAAAGTGTAGATAACGAACTCGTCTGTTTGAGATTATTTTCTG
CTTTCAATATCCCTTCCGCAAACGTTGAATTATTGGAAATGAACGATATACGGGCATTAGCTGTTGAACGTTTTGATCGC
CGTCTTAGTCAAGATGGCAGTTATTTTTTACGTTTACCTTACGAAGATTTCTGTCAGGCATTCGGCTTATCGCCAACGCA
AAAATATGAAAGCGATGGTGGAATTGGTATTGGGGATATGATGAATAAGTTGCTCTACTCCAGTAATTCCAACGATCGCC
GTCAATTTATGCAAACTCAATTTCTGTTTTGGCTACTGGCTGCCATTGATGGACACGCTAAAAACTTTTCTCTCGCCATT
GAAAAACAAGGGCGTTATCACTTATCCCCAGTGTATGACGTACTTTCTGCTTATCCAATGTTAGGCGGAAAAGGTTGGCA
TCACAGTGAATTACAAATGGCAATGAGCTTGCGTAGCACGCAAAAAGGGAAAAAATGGCATTGGAGTAAAATTTATGCTG
AACATTTCTATGCCACAGCTAAGTTTGTCGGATTTAGCTCAAGTGATATGAAACAAGTGATAGAGCAAATTTGCGATACA
GTGCAAGAAACCATTGATAGCGTAGCAACAACACTACCCAAACAGATAGATGAAAATGTACGGGATCAAATATTCACGGG
CATAATGAAACAGGTGCAAAAAGTTTCTATGAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9059.47 Da        Isoelectric Point: 9.7684

>AT48485 WP_010786623.1 NZ_CP009158:2073331-2073570 [Glaesserella parasuis]
MLITTPDMLGNSLRDIRKQKKLSQMQIANQVALRQATISTFEKKTDKATIETLFKLLSGLGYELHIQPRPEKTEGNDEW

Download         Length: 240 bp

>AT48485 NZ_CP009158:2073331-2073570 [Glaesserella parasuis]
ATGTTAATCACGACACCAGATATGCTTGGAAATAGCCTACGCGATATTCGTAAGCAAAAAAAGCTTTCTCAAATGCAAAT
AGCAAATCAAGTAGCTTTAAGACAAGCCACGATTTCCACCTTTGAGAAAAAAACCGATAAAGCCACTATTGAAACATTAT
TCAAGTTACTTTCAGGTTTAGGCTATGAACTACATATCCAACCTCGTCCTGAAAAAACAGAGGGGAACGATGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB U4SAZ6

References