Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1514083..1515770 Replicon chromosome
Accession NZ_CP009158
Organism Glaesserella parasuis strain SH03

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JL26_RS07515 Protein ID WP_038514597.1
Coordinates 1514427..1515770 (-) Length 448 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JL26_RS07510 Protein ID WP_005713145.1
Coordinates 1514083..1514427 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL26_RS07490 1510154..1511104 - 951 WP_005713153.1 ribose-phosphate pyrophosphokinase -
JL26_RS07495 1511132..1511977 - 846 WP_016528415.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
JL26_RS07500 1511979..1512611 - 633 WP_038514594.1 lipoprotein insertase outer membrane protein LolB -
JL26_RS07505 1512729..1514054 - 1326 WP_005713147.1 ATP-dependent RNA helicase SrmB -
JL26_RS07510 1514083..1514427 - 345 WP_005713145.1 helix-turn-helix domain-containing protein Antitoxin
JL26_RS07515 1514427..1515770 - 1344 WP_038514597.1 type II toxin-antitoxin system HipA family toxin Toxin
JL26_RS07520 1515884..1516321 - 438 WP_021110342.1 ribosomal protein S18-alanine N-acetyltransferase -
JL26_RS07525 1516563..1517003 - 441 WP_016528419.1 M23 family metallopeptidase -
JL26_RS07530 1517005..1517418 - 414 WP_005713136.1 DNA polymerase III subunit psi -
JL26_RS07535 1517501..1518442 + 942 WP_021115536.1 16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC -
JL26_RS07540 1518592..1520769 + 2178 WP_038514601.1 bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(161-407)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 448 a.a.        Molecular weight: 51142.12 Da        Isoelectric Point: 4.9426

>T48484 WP_038514597.1 NZ_CP009158:c1515770-1514427 [Glaesserella parasuis]
MQIEPLTLQAYIADRWQDIAILTFQADYSLNDFSYLYDLAEILSDNDKAVSFNYPVEFFPYRSVSGWFAFLDDIVPSGAS
RRYWLQKLDIAHLPTAQQNYLLLKQGTIAPVGHLRVKQAVSSFIENEPPRLFEIDDVINRQADFLEYANQRGAMAGGATG
AGGEAPKLLLRQTATQQVWIDNLQQGDAADDFYLVKFPRGKRSVIDCDILRAEFHYYHELASMGFDTIDTTKMRLEEGER
YPSLWLPRFDFYRNEQGKMARYAVESVYAMLEKGAGSLLDHEKVIRQLIAKIETSHLVETGMFFDKQAFVIEWVRRDLLN
IAFGNSDNHGRNTAFLRNQNRIWLAPIYDFAPMKADPEGIPRTTMWDSKGHPALELGGEYRFDLIAEQLDDLCPADKLLD
ALRQTAQQLVGLKARLEARGVPTAILTYPSISLDYLPEKLQRWQLLS

Download         Length: 1344 bp

>T48484 NZ_CP009158:c1515770-1514427 [Glaesserella parasuis]
ATGCAAATCGAACCGCTTACACTTCAGGCCTATATTGCTGATCGTTGGCAGGATATTGCTATTTTGACCTTTCAGGCTGA
TTATAGCCTCAATGATTTTAGCTATCTCTATGATTTAGCAGAGATTTTAAGTGATAATGATAAGGCAGTTTCATTTAACT
ATCCTGTGGAGTTTTTCCCATACCGTAGTGTATCGGGCTGGTTTGCATTTTTAGATGATATAGTTCCTTCTGGAGCAAGT
CGGCGTTATTGGTTGCAAAAACTTGATATTGCTCATTTGCCGACAGCTCAACAAAACTATTTGTTATTAAAACAAGGTAC
GATTGCACCTGTCGGGCATTTACGAGTGAAGCAAGCGGTCAGTTCTTTTATCGAAAATGAACCCCCTCGCTTATTTGAAA
TAGATGATGTTATCAATCGCCAAGCTGATTTTTTGGAATATGCTAATCAGCGTGGGGCAATGGCTGGCGGTGCAACGGGG
GCTGGTGGCGAAGCGCCGAAATTATTGCTACGCCAAACAGCCACTCAGCAAGTTTGGATTGATAATCTACAACAAGGTGA
CGCTGCCGACGATTTCTATTTAGTCAAGTTTCCGCGTGGGAAACGTAGTGTAATAGATTGCGATATATTGAGAGCTGAAT
TTCACTATTATCACGAATTAGCCTCAATGGGTTTTGACACCATTGATACGACAAAAATGCGATTGGAAGAAGGCGAACGT
TACCCGTCGTTGTGGTTACCTCGTTTTGATTTTTATCGTAATGAACAGGGGAAAATGGCTCGTTATGCCGTTGAATCTGT
TTATGCTATGTTAGAAAAAGGGGCTGGCTCTTTGCTGGATCACGAAAAGGTTATTCGTCAGTTGATTGCTAAAATTGAAA
CCTCTCATTTGGTTGAAACAGGAATGTTTTTTGATAAACAAGCTTTTGTGATCGAGTGGGTAAGGCGAGATTTATTGAAT
ATCGCCTTTGGAAATAGCGATAATCACGGACGAAATACGGCTTTCTTACGCAATCAAAATCGTATCTGGCTTGCTCCAAT
TTATGATTTTGCCCCAATGAAAGCAGATCCTGAAGGTATTCCTCGCACGACAATGTGGGATAGTAAAGGTCACCCTGCAT
TAGAATTAGGCGGTGAATATCGTTTTGATCTGATTGCAGAACAGCTTGATGATTTATGTCCAGCCGACAAGTTATTGGAT
GCTTTGCGTCAAACGGCTCAACAGCTTGTCGGACTTAAAGCACGTTTAGAAGCAAGGGGCGTTCCAACGGCGATTTTGAC
GTACCCTTCAATCAGTTTGGACTATTTACCTGAAAAATTACAACGTTGGCAATTATTATCATAA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13207.48 Da        Isoelectric Point: 10.2782

>AT48484 WP_005713145.1 NZ_CP009158:c1514427-1514083 [Glaesserella parasuis]
MEEIKQARASKSKKTLDIYQRATVRDEIARKLLLNEMSLGQALKYLRLHLLAMKQERYAEIVKVSRKTLSDLENDKGNYS
IDIINQVLRPFELQLGVVPINKTLLRQVLNEQAV

Download         Length: 345 bp

>AT48484 NZ_CP009158:c1514427-1514083 [Glaesserella parasuis]
ATGGAAGAGATCAAACAGGCGAGAGCCTCTAAAAGTAAAAAAACGTTAGATATTTATCAGCGAGCGACTGTGCGAGACGA
AATTGCTCGTAAGCTATTGCTCAATGAGATGAGTTTAGGGCAGGCGTTGAAATATCTACGTTTACATCTACTGGCAATGA
AACAAGAGCGTTATGCGGAGATTGTCAAAGTTTCTCGCAAAACGTTATCTGATTTAGAAAATGATAAGGGAAATTACAGT
ATTGATATTATCAATCAGGTGTTACGCCCCTTTGAATTACAGCTTGGCGTTGTGCCAATAAACAAAACATTACTCAGACA
AGTTTTAAATGAACAAGCGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References