Detailed information of TA system TA048479

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 547936..548558
• Replicon: chromosome
• Accession: NZ_CP009158
• Organism: Glaesserella parasuis strain SH03

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A836YYE8
• Locus tag: JL26_RS02925
• Protein ID: WP_005715063.1
• Coordinates: 548376..548558 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A837B0B6
• Locus tag: JL26_RS02920
• Protein ID: WP_005715065.1
• Coordinates: 547936..548349 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JL26_RS02885	543465..543830	-	366	WP_016528090.1	hypothetical protein	-
JL26_RS02890	543836..544567	-	732	WP_016528089.1	helix-turn-helix transcriptional regulator	-
JL26_RS02895	544702..544926	+	225	WP_016528088.1	helix-turn-helix domain-containing protein	-
JL26_RS02900	544970..545152	+	183	WP_016528087.1	hypothetical protein	-
JL26_RS02905	545130..546020	+	891	WP_026916583.1	replication protein	-
JL26_RS02910	546020..547375	+	1356	WP_026916582.1	AAA family ATPase	-
JL26_RS02915	547474..547902	+	429	WP_038515080.1	recombination protein NinB	-
JL26_RS02920	547936..548349	-	414	WP_005715065.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JL26_RS02925	548376..548558	-	183	WP_005715063.1	type II toxin-antitoxin system HicA family toxin	Toxin
JL26_RS12305	548657..548833	+	177	WP_016528082.1	hypothetical protein	-
JL26_RS02930	548805..549383	+	579	WP_038513329.1	recombination protein NinG	-
JL26_RS02935	549373..549843	+	471	WP_038513800.1	antitermination protein	-
JL26_RS11665	549895..550744	+	850	Protein_587	transposase	-
JL26_RS02945	550799..551107	-	309	WP_131271302.1	hypothetical protein	-
JL26_RS02950	551144..551506	-	363	WP_035492440.1	DUF805 domain-containing protein	-
JL26_RS02955	551640..552038	+	399	WP_035492438.1	helix-turn-helix transcriptional regulator	-
JL26_RS02960	552087..552557	-	471	Protein_591	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	535256..563945	28689

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-130)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6678.80 Da
• Isoelectric Point: 10.6602

>T48479 WP_005715063.1 NZ_CP009158:c548558-548376 [Glaesserella parasuis]
VDSKTIIKMIEADGWYLVATSGSHHQFKHPTKQGRVTVPHPKKDLKKGTELSILKQAGLK

Nucleotide

• Length: 183 bp

>T48479 NZ_CP009158:c548558-548376 [Glaesserella parasuis]
GTGGATAGCAAAACCATAATTAAAATGATTGAAGCGGACGGTTGGTACTTAGTTGCAACAAGTGGAAGCCACCATCAATT
CAAACATCCAACTAAACAAGGGCGAGTAACAGTGCCTCATCCGAAAAAGGATTTAAAAAAAGGAACTGAACTCTCAATAC
TTAAACAAGCGGGGCTAAAATAG

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15401.47 Da
• Isoelectric Point: 4.3988

>AT48479 WP_005715065.1 NZ_CP009158:c548349-547936 [Glaesserella parasuis]
MLYPIAIEPGDETHAYGVIVPDIPGCFSAGDTLEEAYQNVKEAIVFHLEGLVEDGEEIPMPTSIDNHRKNPDFAEYDFFF
GFVDVDISHLLGKAERINITLPSYLIKRIDDFVAVHKEYKNRSNFLAKIAADKILTA

Nucleotide

• Length: 414 bp

>AT48479 NZ_CP009158:c548349-547936 [Glaesserella parasuis]
ATGTTATACCCAATTGCAATTGAACCAGGTGACGAAACTCACGCTTACGGCGTTATCGTGCCTGATATTCCAGGGTGCTT
CTCTGCTGGCGATACCCTCGAAGAAGCATATCAAAATGTCAAAGAAGCCATCGTGTTCCACCTTGAAGGCTTAGTTGAAG
ATGGAGAAGAAATTCCGATGCCAACCTCCATTGATAACCACCGCAAAAACCCTGATTTTGCAGAATATGACTTCTTTTTC
GGCTTTGTTGATGTTGATATTAGCCATTTACTCGGAAAAGCCGAACGCATCAACATCACCCTCCCTAGCTATCTCATCAA
ACGCATTGATGATTTTGTTGCGGTTCACAAAGAGTATAAAAACCGTAGCAACTTCTTAGCTAAAATCGCAGCGGATAAAA
TCTTAACCGCTTAA

Structures

Toxin

• AlphaFold DB: A0A836YYE8

Antitoxin

• AlphaFold DB: A0A837B0B6