Detailed information of TA system TA048478

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 469473..470250
• Replicon: chromosome
• Accession: NZ_CP009158
• Organism: Glaesserella parasuis strain SH03

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: A0A836YXW5
• Locus tag: JL26_RS02555
• Protein ID: WP_016527794.1
• Coordinates: 469473..469973 (-)
• Length: 167 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: U4SPD7
• Locus tag: JL26_RS02560
• Protein ID: WP_005710653.1
• Coordinates: 469963..470250 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JL26_RS11640	464598..464753	-	156	WP_005710668.1	YoaH family protein	-
JL26_RS02525	464771..465499	-	729	WP_038513732.1	tRNA pseudouridine(65) synthase TruC	-
JL26_RS02530	465496..465810	-	315	WP_005710664.1	YqcC family protein	-
JL26_RS02535	465852..466766	-	915	WP_021109673.1	N-acetylmuramic acid 6-phosphate etherase	-
JL26_RS02540	466778..467893	-	1116	WP_012621874.1	anhydro-N-acetylmuramic acid kinase	-
JL26_RS02545	468048..468383	-	336	WP_005710658.1	outer membrane protein assembly factor BamE	-
JL26_RS02550	468444..469445	-	1002	WP_005710656.1	nucleoid-associated protein YejK	-
JL26_RS02555	469473..469973	-	501	WP_016527794.1	GNAT family N-acetyltransferase	Toxin
JL26_RS02560	469963..470250	-	288	WP_005710653.1	DUF1778 domain-containing protein	Antitoxin
JL26_RS02565	470396..470785	+	390	WP_016527795.1	RidA family protein	-
JL26_RS02570	470789..471526	+	738	WP_038513738.1	peptidoglycan editing factor PgeF	-
JL26_RS02575	471701..473278	+	1578	WP_038513740.1	FAD-binding protein	-
JL26_RS02580	473383..473883	+	501	WP_021109667.1	CvpA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (4-87)

Sequences

Toxin

Protein

• Length: 167 a.a.
• Molecular weight: 19081.26 Da
• Isoelectric Point: 9.2835

>T48478 WP_016527794.1 NZ_CP009158:c469973-469473 [Glaesserella parasuis]
MKSKFIEEPLTKHHQREAFDCGNLEMNRFFKQYARQSHEKGTSKTYISRHLDSQQIIGFYTITLSALDQQHLPELCKKRF
GYYPIPLFTLARLAVDIRYQKQGIGGMLLVKALKRCAIVAEQVGGIGLLIEAKDEDISRWYQSYGAIPLENMPLTLILLF
DTIKGL

Nucleotide

• Length: 501 bp

>T48478 NZ_CP009158:c469973-469473 [Glaesserella parasuis]
ATGAAGAGTAAGTTTATTGAAGAGCCTTTAACGAAGCATCATCAACGTGAAGCCTTTGATTGCGGAAATCTAGAGATGAA
CCGATTTTTTAAACAATACGCTCGGCAATCTCACGAAAAAGGGACATCAAAAACTTACATTAGCCGACACTTAGACAGTC
AACAGATTATCGGATTTTATACAATCACCTTAAGTGCATTAGACCAGCAACACTTACCCGAACTATGCAAAAAACGTTTT
GGCTACTACCCTATTCCGCTCTTTACATTAGCAAGACTTGCAGTGGATATTCGCTATCAAAAACAAGGCATTGGCGGAAT
GCTGTTAGTTAAAGCTCTCAAACGCTGTGCCATCGTTGCCGAACAAGTCGGGGGAATTGGGCTTCTCATTGAAGCAAAAG
ATGAAGACATTTCTCGTTGGTATCAATCTTATGGTGCTATTCCATTGGAAAATATGCCATTAACCTTAATTCTACTCTTT
GATACAATCAAAGGACTTTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10917.47 Da
• Isoelectric Point: 6.4650

>AT48478 WP_005710653.1 NZ_CP009158:c470250-469963 [Glaesserella parasuis]
MPQIANALNDRMSIRISTEDKQTLIRAVALTHTNITEFVLQRILPSAREIIQQYDNRQFSPQDLSLIMELLDNPPKANTK
LQQAAKLAKESYHEE

Nucleotide

• Length: 288 bp

>AT48478 NZ_CP009158:c470250-469963 [Glaesserella parasuis]
ATGCCACAAATTGCAAATGCCCTTAACGATAGAATGTCTATTCGCATTAGTACGGAAGACAAGCAGACTTTAATTAGAGC
CGTTGCACTTACCCATACGAATATTACGGAATTTGTATTACAACGTATTTTGCCTAGTGCCAGAGAAATTATTCAGCAGT
ATGATAATCGGCAATTTTCACCGCAAGATCTCTCGTTGATTATGGAATTGCTTGATAATCCGCCGAAAGCTAATACAAAA
CTACAACAAGCGGCGAAATTAGCAAAGGAAAGCTATCATGAAGAGTAA

Structures

Toxin

• AlphaFold DB: A0A836YXW5

Antitoxin

• AlphaFold DB: U4SPD7