Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 469473..470250 Replicon chromosome
Accession NZ_CP009158
Organism Glaesserella parasuis strain SH03

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A836YXW5
Locus tag JL26_RS02555 Protein ID WP_016527794.1
Coordinates 469473..469973 (-) Length 167 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID U4SPD7
Locus tag JL26_RS02560 Protein ID WP_005710653.1
Coordinates 469963..470250 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL26_RS11640 464598..464753 - 156 WP_005710668.1 YoaH family protein -
JL26_RS02525 464771..465499 - 729 WP_038513732.1 tRNA pseudouridine(65) synthase TruC -
JL26_RS02530 465496..465810 - 315 WP_005710664.1 YqcC family protein -
JL26_RS02535 465852..466766 - 915 WP_021109673.1 N-acetylmuramic acid 6-phosphate etherase -
JL26_RS02540 466778..467893 - 1116 WP_012621874.1 anhydro-N-acetylmuramic acid kinase -
JL26_RS02545 468048..468383 - 336 WP_005710658.1 outer membrane protein assembly factor BamE -
JL26_RS02550 468444..469445 - 1002 WP_005710656.1 nucleoid-associated protein YejK -
JL26_RS02555 469473..469973 - 501 WP_016527794.1 GNAT family N-acetyltransferase Toxin
JL26_RS02560 469963..470250 - 288 WP_005710653.1 DUF1778 domain-containing protein Antitoxin
JL26_RS02565 470396..470785 + 390 WP_016527795.1 RidA family protein -
JL26_RS02570 470789..471526 + 738 WP_038513738.1 peptidoglycan editing factor PgeF -
JL26_RS02575 471701..473278 + 1578 WP_038513740.1 FAD-binding protein -
JL26_RS02580 473383..473883 + 501 WP_021109667.1 CvpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(4-87)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 19081.26 Da        Isoelectric Point: 9.2835

>T48478 WP_016527794.1 NZ_CP009158:c469973-469473 [Glaesserella parasuis]
MKSKFIEEPLTKHHQREAFDCGNLEMNRFFKQYARQSHEKGTSKTYISRHLDSQQIIGFYTITLSALDQQHLPELCKKRF
GYYPIPLFTLARLAVDIRYQKQGIGGMLLVKALKRCAIVAEQVGGIGLLIEAKDEDISRWYQSYGAIPLENMPLTLILLF
DTIKGL

Download         Length: 501 bp

>T48478 NZ_CP009158:c469973-469473 [Glaesserella parasuis]
ATGAAGAGTAAGTTTATTGAAGAGCCTTTAACGAAGCATCATCAACGTGAAGCCTTTGATTGCGGAAATCTAGAGATGAA
CCGATTTTTTAAACAATACGCTCGGCAATCTCACGAAAAAGGGACATCAAAAACTTACATTAGCCGACACTTAGACAGTC
AACAGATTATCGGATTTTATACAATCACCTTAAGTGCATTAGACCAGCAACACTTACCCGAACTATGCAAAAAACGTTTT
GGCTACTACCCTATTCCGCTCTTTACATTAGCAAGACTTGCAGTGGATATTCGCTATCAAAAACAAGGCATTGGCGGAAT
GCTGTTAGTTAAAGCTCTCAAACGCTGTGCCATCGTTGCCGAACAAGTCGGGGGAATTGGGCTTCTCATTGAAGCAAAAG
ATGAAGACATTTCTCGTTGGTATCAATCTTATGGTGCTATTCCATTGGAAAATATGCCATTAACCTTAATTCTACTCTTT
GATACAATCAAAGGACTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10917.47 Da        Isoelectric Point: 6.4650

>AT48478 WP_005710653.1 NZ_CP009158:c470250-469963 [Glaesserella parasuis]
MPQIANALNDRMSIRISTEDKQTLIRAVALTHTNITEFVLQRILPSAREIIQQYDNRQFSPQDLSLIMELLDNPPKANTK
LQQAAKLAKESYHEE

Download         Length: 288 bp

>AT48478 NZ_CP009158:c470250-469963 [Glaesserella parasuis]
ATGCCACAAATTGCAAATGCCCTTAACGATAGAATGTCTATTCGCATTAGTACGGAAGACAAGCAGACTTTAATTAGAGC
CGTTGCACTTACCCATACGAATATTACGGAATTTGTATTACAACGTATTTTGCCTAGTGCCAGAGAAATTATTCAGCAGT
ATGATAATCGGCAATTTTCACCGCAAGATCTCTCGTTGATTATGGAATTGCTTGATAATCCGCCGAAAGCTAATACAAAA
CTACAACAAGCGGCGAAATTAGCAAAGGAAAGCTATCATGAAGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836YXW5

Antitoxin

Source ID Structure
AlphaFold DB U4SPD7

References