Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 212819..213469 Replicon chromosome
Accession NZ_CP009158
Organism Glaesserella parasuis strain SH03

Toxin (Protein)


Gene name hicA Uniprot ID A0A7H8UVF2
Locus tag JL26_RS01305 Protein ID WP_016527644.1
Coordinates 213293..213469 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A836YYB9
Locus tag JL26_RS01300 Protein ID WP_016527643.1
Coordinates 212819..213235 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL26_RS01260 209028..209462 + 435 WP_035490842.1 hypothetical protein -
JL26_RS01265 209476..210465 + 990 WP_016527636.1 encapsulin -
JL26_RS01270 210477..210755 + 279 Protein_258 hypothetical protein -
JL26_RS01275 210821..211198 + 378 WP_016527638.1 hypothetical protein -
JL26_RS01280 211199..211546 + 348 WP_035490848.1 hypothetical protein -
JL26_RS01285 211546..211914 + 369 WP_035490850.1 hypothetical protein -
JL26_RS01290 211911..212285 + 375 WP_016527641.1 hypothetical protein -
JL26_RS01295 212294..212773 + 480 WP_016527642.1 hypothetical protein -
JL26_RS01300 212819..213235 - 417 WP_016527643.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JL26_RS01305 213293..213469 - 177 WP_016527644.1 type II toxin-antitoxin system HicA family toxin Toxin
JL26_RS01310 213567..214238 + 672 WP_038513526.1 hypothetical protein -
JL26_RS01315 214343..214801 + 459 WP_016527646.1 hypothetical protein -
JL26_RS01320 215027..217477 + 2451 WP_038513529.1 phage tail length tape measure family protein -
JL26_RS01325 217482..217811 + 330 WP_016527647.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 151866..226039 74173


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-60)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6640.74 Da        Isoelectric Point: 10.6914

>T48477 WP_016527644.1 NZ_CP009158:c213469-213293 [Glaesserella parasuis]
VKQSEFLRWLKANGVEVENGTKHLKLYYNGKRSHLPKHPSQELKTGLVEGVKKQLGLK

Download         Length: 177 bp

>T48477 NZ_CP009158:c213469-213293 [Glaesserella parasuis]
GTGAAGCAAAGCGAATTCCTTAGGTGGCTAAAGGCTAACGGGGTAGAAGTTGAGAATGGCACAAAACATTTAAAGCTCTA
CTACAACGGCAAAAGAAGCCACCTCCCCAAACACCCTAGCCAAGAGTTAAAAACTGGTTTAGTGGAAGGGGTTAAAAAGC
AACTAGGCTTAAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15470.82 Da        Isoelectric Point: 4.5304

>AT48477 WP_016527643.1 NZ_CP009158:c213235-212819 [Glaesserella parasuis]
MFYPALFTPAEEGGFVVTFPDIPEAITQGDTFEEAMEMAEDVLLSSVEIYFDDERAFPLSRPAGIYETSVFIPESVYAKI
LLHNTMCEKFISKAEVARLNNIKPPEIHRILAPRHTTRIDTIGRILASLGRPLQLSLA

Download         Length: 417 bp

>AT48477 NZ_CP009158:c213235-212819 [Glaesserella parasuis]
ATGTTTTATCCAGCGTTATTTACCCCTGCCGAAGAAGGGGGATTTGTGGTGACATTTCCAGATATTCCAGAAGCGATCAC
TCAAGGTGATACATTTGAAGAAGCGATGGAAATGGCTGAAGATGTTTTATTATCTAGTGTAGAAATCTATTTCGATGATG
AGCGAGCGTTCCCGCTATCACGCCCTGCTGGAATTTATGAAACATCTGTGTTTATACCAGAGAGCGTTTATGCGAAAATT
TTACTGCACAACACTATGTGCGAAAAATTTATCTCAAAAGCAGAAGTTGCTCGCCTAAATAATATTAAGCCGCCAGAAAT
CCATCGGATTTTAGCCCCAAGACATACAACTAGGATTGACACGATTGGCAGAATCTTGGCAAGTCTTGGCAGACCATTGC
AGCTATCGCTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H8UVF2

Antitoxin

Source ID Structure
AlphaFold DB A0A836YYB9

References