Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 52536..53158 Replicon chromosome
Accession NZ_CP009158
Organism Glaesserella parasuis strain SH03

Toxin (Protein)


Gene name hicA Uniprot ID A0A836YYE8
Locus tag JL26_RS00320 Protein ID WP_005715063.1
Coordinates 52976..53158 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A837B0B6
Locus tag JL26_RS00315 Protein ID WP_005715065.1
Coordinates 52536..52949 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL26_RS00280 47758..48171 - 414 WP_021114968.1 hypothetical protein -
JL26_RS00285 48235..48888 - 654 WP_038513322.1 LexA family transcriptional regulator -
JL26_RS00290 49024..49230 + 207 WP_012621794.1 helix-turn-helix transcriptional regulator -
JL26_RS00295 49570..49752 + 183 WP_016528087.1 hypothetical protein -
JL26_RS00300 49730..50620 + 891 WP_026916583.1 replication protein -
JL26_RS00305 50620..51975 + 1356 WP_026916582.1 AAA family ATPase -
JL26_RS00310 52074..52502 + 429 WP_038515080.1 recombination protein NinB -
JL26_RS00315 52536..52949 - 414 WP_005715065.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JL26_RS00320 52976..53158 - 183 WP_005715063.1 type II toxin-antitoxin system HicA family toxin Toxin
JL26_RS12260 53257..53433 + 177 WP_016528082.1 hypothetical protein -
JL26_RS00325 53405..53983 + 579 WP_038513329.1 recombination protein NinG -
JL26_RS11295 53973..54437 + 465 WP_051617452.1 antitermination protein -
JL26_RS11300 54468..55332 + 865 Protein_67 IS256 family transposase -
JL26_RS00345 55499..57385 - 1887 WP_010786228.1 molecular chaperone HtpG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 27879..55332 27453
- flank IS/Tn - - 55042..55332 290


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-130)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6678.80 Da        Isoelectric Point: 10.6602

>T48476 WP_005715063.1 NZ_CP009158:c53158-52976 [Glaesserella parasuis]
VDSKTIIKMIEADGWYLVATSGSHHQFKHPTKQGRVTVPHPKKDLKKGTELSILKQAGLK

Download         Length: 183 bp

>T48476 NZ_CP009158:c53158-52976 [Glaesserella parasuis]
GTGGATAGCAAAACCATAATTAAAATGATTGAAGCGGACGGTTGGTACTTAGTTGCAACAAGTGGAAGCCACCATCAATT
CAAACATCCAACTAAACAAGGGCGAGTAACAGTGCCTCATCCGAAAAAGGATTTAAAAAAAGGAACTGAACTCTCAATAC
TTAAACAAGCGGGGCTAAAATAG

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15401.47 Da        Isoelectric Point: 4.3988

>AT48476 WP_005715065.1 NZ_CP009158:c52949-52536 [Glaesserella parasuis]
MLYPIAIEPGDETHAYGVIVPDIPGCFSAGDTLEEAYQNVKEAIVFHLEGLVEDGEEIPMPTSIDNHRKNPDFAEYDFFF
GFVDVDISHLLGKAERINITLPSYLIKRIDDFVAVHKEYKNRSNFLAKIAADKILTA

Download         Length: 414 bp

>AT48476 NZ_CP009158:c52949-52536 [Glaesserella parasuis]
ATGTTATACCCAATTGCAATTGAACCAGGTGACGAAACTCACGCTTACGGCGTTATCGTGCCTGATATTCCAGGGTGCTT
CTCTGCTGGCGATACCCTCGAAGAAGCATATCAAAATGTCAAAGAAGCCATCGTGTTCCACCTTGAAGGCTTAGTTGAAG
ATGGAGAAGAAATTCCGATGCCAACCTCCATTGATAACCACCGCAAAAACCCTGATTTTGCAGAATATGACTTCTTTTTC
GGCTTTGTTGATGTTGATATTAGCCATTTACTCGGAAAAGCCGAACGCATCAACATCACCCTCCCTAGCTATCTCATCAA
ACGCATTGATGATTTTGTTGCGGTTCACAAAGAGTATAAAAACCGTAGCAACTTCTTAGCTAAAATCGCAGCGGATAAAA
TCTTAACCGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836YYE8

Antitoxin

Source ID Structure
AlphaFold DB A0A837B0B6

References