Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 3456457..3457112 Replicon chromosome
Accession NZ_CP009157
Organism Burkholderia pseudomallei strain TSV202

Toxin (Protein)


Gene name relE Uniprot ID A0A0F6LEW6
Locus tag X994_RS30275 Protein ID WP_006027262.1
Coordinates 3456816..3457112 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag X994_RS30270 Protein ID WP_004202809.1
Coordinates 3456457..3456813 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
X994_RS30240 3452589..3453347 + 759 WP_004521940.1 cytochrome c1 -
X994_RS30245 3453440..3454051 + 612 WP_004185176.1 glutathione S-transferase N-terminal domain-containing protein -
X994_RS30250 3454121..3454642 + 522 WP_004199890.1 ClpXP protease specificity-enhancing factor -
X994_RS30260 3454864..3455361 + 498 WP_004199888.1 terminase -
X994_RS30265 3455358..3456413 + 1056 WP_043299954.1 phage portal protein -
X994_RS30270 3456457..3456813 - 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
X994_RS30275 3456816..3457112 - 297 WP_006027262.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
X994_RS41275 3457780..3459036 + 1257 WP_004552667.1 AAA family ATPase -
X994_RS30285 3459081..3459656 + 576 WP_198014201.1 DUF4276 family protein -
X994_RS30290 3460430..3460756 + 327 WP_004545634.1 hypothetical protein -
X994_RS30295 3460749..3461160 + 412 Protein_3067 phage tail protein I -
X994_RS30300 3461058..3461660 + 603 WP_080311446.1 site-specific DNA-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3455047..3464492 9445


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10844.65 Da        Isoelectric Point: 10.1723

>T48475 WP_006027262.1 NZ_CP009157:c3457112-3456816 [Burkholderia pseudomallei]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T48475 NZ_CP009157:c3457112-3456816 [Burkholderia pseudomallei]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCGTGCGACGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT48475 WP_004202809.1 NZ_CP009157:c3456813-3456457 [Burkholderia pseudomallei]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT48475 NZ_CP009157:c3456813-3456457 [Burkholderia pseudomallei]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGGAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6LEW6

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References