Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1177815..1178470 Replicon chromosome
Accession NZ_CP009151
Organism Burkholderia pseudomallei B03

Toxin (Protein)


Gene name relE Uniprot ID A0A0H2WL39
Locus tag X995_RS18740 Protein ID WP_004199884.1
Coordinates 1178174..1178470 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag X995_RS18735 Protein ID WP_004202809.1
Coordinates 1177815..1178171 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
X995_RS18705 1173949..1174707 + 759 WP_004521940.1 cytochrome c1 -
X995_RS18710 1174800..1175411 + 612 WP_004185176.1 glutathione S-transferase N-terminal domain-containing protein -
X995_RS18715 1175481..1176002 + 522 WP_004527881.1 ClpXP protease specificity-enhancing factor -
X995_RS18725 1176224..1176719 + 496 Protein_1050 terminase -
X995_RS18730 1176716..1177771 + 1056 WP_038724553.1 phage portal protein -
X995_RS18735 1177815..1178171 - 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
X995_RS18740 1178174..1178470 - 297 WP_004199884.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
X995_RS36115 1179138..1180394 + 1257 WP_004552667.1 AAA family ATPase -
X995_RS18750 1180439..1181014 + 576 WP_198014201.1 DUF4276 family protein -
X995_RS18755 1181787..1182113 + 327 WP_038759954.1 baseplate assembly protein -
X995_RS18760 1182106..1182517 + 412 Protein_1057 phage tail protein I -
X995_RS18765 1182602..1183018 + 417 WP_076926800.1 DNA methylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1176405..1184470 8065


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(8-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10840.66 Da        Isoelectric Point: 10.1723

>T48470 WP_004199884.1 NZ_CP009151:c1178470-1178174 [Burkholderia pseudomallei B03]
MFKVLTPPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T48470 NZ_CP009151:c1178470-1178174 [Burkholderia pseudomallei B03]
ATGTTCAAAGTTCTGACGCCCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCGTGCGACGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT48470 WP_004202809.1 NZ_CP009151:c1178171-1177815 [Burkholderia pseudomallei B03]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT48470 NZ_CP009151:c1178171-1177815 [Burkholderia pseudomallei B03]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGGAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAGGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTCGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2WL39

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References