Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2580883..2581538 Replicon chromosome
Accession NZ_CP009148
Organism Burkholderia mallei strain FMH 23344

Toxin (Protein)


Gene name relE Uniprot ID A0A0H2WL39
Locus tag DM51_RS21615 Protein ID WP_004199884.1
Coordinates 2580883..2581179 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag DM51_RS21620 Protein ID WP_004202809.1
Coordinates 2581182..2581538 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM51_RS21585 2576409..2576837 + 429 WP_004199881.1 helix-turn-helix domain-containing protein -
DM51_RS21590 2577157..2577939 - 783 WP_004201278.1 flagellar biosynthetic protein FliR -
DM51_RS21595 2578058..2578330 - 273 WP_004199882.1 flagellar biosynthesis protein FliQ -
DM51_RS21600 2578356..2578907 - 552 Protein_2281 flagellar type III secretion system pore protein FliP -
DM51_RS21615 2580883..2581179 + 297 WP_004199884.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DM51_RS21620 2581182..2581538 + 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
DM51_RS21625 2581582..2582637 - 1056 WP_004199886.1 phage portal protein -
DM51_RS21630 2582634..2583131 - 498 WP_004199888.1 terminase -
DM51_RS21640 2583353..2583874 - 522 WP_004199890.1 ClpXP protease specificity-enhancing factor -
DM51_RS21645 2583944..2584555 - 612 WP_004185176.1 glutathione S-transferase N-terminal domain-containing protein -
DM51_RS21650 2584648..2585406 - 759 WP_004199892.1 cytochrome c1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2578955..2582948 3993


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(8-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10840.66 Da        Isoelectric Point: 10.1723

>T48465 WP_004199884.1 NZ_CP009148:2580883-2581179 [Burkholderia mallei]
MFKVLTPPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T48465 NZ_CP009148:2580883-2581179 [Burkholderia mallei]
ATGTTCAAAGTTCTGACGCCCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTATTTCGTGCGGCGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT48465 WP_004202809.1 NZ_CP009148:2581182-2581538 [Burkholderia mallei]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT48465 NZ_CP009148:2581182-2581538 [Burkholderia mallei]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2WL39

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References