48457

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 597016..597515 Replicon plasmid pSymA
Accession NZ_CP009145
Organism Sinorhizobium meliloti strain RMO17

Toxin (Protein)


Gene name relE Uniprot ID Q92YA6
Locus tag DU99_RS20340 Protein ID WP_010967939.1
Coordinates 597342..597515 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A843ZXX9
Locus tag DU99_RS35660 Protein ID WP_014990215.1
Coordinates 597016..597345 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DU99_RS20310 592044..592388 + 345 WP_013845644.1 hypothetical protein -
DU99_RS36195 592468..592644 + 177 WP_013845643.1 hypothetical protein -
DU99_RS20315 592770..593663 - 894 WP_010967943.1 LysR family transcriptional regulator -
DU99_RS20320 593755..594198 + 444 WP_010967942.1 PACE efflux transporter -
DU99_RS20325 594315..594653 + 339 WP_013845641.1 SDR family oxidoreductase -
DU99_RS33260 594637..594978 - 342 Protein_589 hypothetical protein -
DU99_RS20330 595362..596655 - 1294 Protein_590 alpha/beta hydrolase -
DU99_RS33265 596896..597081 - 186 WP_013845639.1 hypothetical protein -
DU99_RS35660 597016..597345 + 330 WP_014990215.1 hypothetical protein Antitoxin
DU99_RS20340 597342..597515 + 174 WP_010967939.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DU99_RS20345 597613..597918 - 306 WP_013845638.1 hypothetical protein -
DU99_RS20350 598238..598597 - 360 WP_013845635.1 glyoxalase/bleomycin resistance/dioxygenase family protein -
DU99_RS20355 599192..599443 + 252 WP_003534243.1 GlsB/YeaQ/YmgE family stress response membrane protein -
DU99_RS20360 599471..599956 + 486 WP_010967936.1 YidB family protein -
DU99_RS20365 600335..601651 - 1317 WP_013845634.1 aspartate aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB 1..1466845 1466845


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-71)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6497.32 Da        Isoelectric Point: 5.7733

>T48457 WP_010967939.1 NZ_CP009145:597342-597515 [Sinorhizobium meliloti]
MKLVWARYALDDRDAIFSYIERENPRAAVHVDEEVVSAGRPLDFPESRRPGRIAGTP

Download         Length: 174 bp

>T48457 NZ_CP009145:597342-597515 [Sinorhizobium meliloti]
ATGAAGCTCGTCTGGGCGCGATATGCGCTTGACGATCGCGACGCCATCTTCAGCTACATCGAACGAGAGAATCCGAGGGC
GGCGGTCCACGTTGACGAGGAGGTCGTCAGCGCTGGTCGTCCGCTGGACTTTCCCGAAAGCCGCCGCCCTGGCCGGATTG
CCGGAACTCCATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12067.72 Da        Isoelectric Point: 11.1401

>AT48457 WP_014990215.1 NZ_CP009145:597016-597345 [Sinorhizobium meliloti]
VSERLLLIALLALGPFRASQRHTGRPALLRRGPQTAAGAVEEHFIQLRAPLWLITLGGFSHREAHDAWFRAKVLRALEDT
RPDADDADADAHFQERRAAALRKAAAGDR

Download         Length: 330 bp

>AT48457 NZ_CP009145:597016-597345 [Sinorhizobium meliloti]
GTGAGCGAGCGCCTTCTGCTCATCGCCCTCCTGGCCCTCGGTCCGTTCCGAGCCAGCCAGCGGCATACCGGTCGTCCTGC
TCTGCTACGGCGTGGCCCCCAAACGGCCGCCGGCGCGGTCGAGGAGCACTTCATCCAACTCCGCGCTCCGCTGTGGCTGA
TCACGCTCGGCGGTTTCAGCCACAGAGAGGCTCACGACGCTTGGTTCCGCGCCAAAGTTTTGCGGGCACTCGAGGACACT
CGACCCGATGCGGACGACGCCGACGCCGATGCGCACTTTCAAGAGCGCCGCGCCGCAGCTTTGCGCAAGGCTGCGGCGGG
TGATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q92YA6

Antitoxin

Source ID Structure
AlphaFold DB A0A843ZXX9

References