48448

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2232325..2232979 Replicon chromosome
Accession NZ_CP009144
Organism Sinorhizobium meliloti strain RMO17

Toxin (Protein)


Gene name hicA Uniprot ID H0G1A3
Locus tag DU99_RS10690 Protein ID WP_003530010.1
Coordinates 2232325..2232513 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q92NX0
Locus tag DU99_RS10695 Protein ID WP_010969659.1
Coordinates 2232518..2232979 (+) Length 154 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DU99_RS10675 2228891..2230201 + 1311 WP_010969656.1 HlyD family type I secretion periplasmic adaptor subunit -
DU99_RS10680 2230226..2231197 - 972 WP_017265202.1 glycosyltransferase family 2 protein -
DU99_RS10685 2231378..2232148 - 771 WP_010969658.1 hypothetical protein -
DU99_RS10690 2232325..2232513 + 189 WP_003530010.1 type II toxin-antitoxin system HicA family toxin Toxin
DU99_RS10695 2232518..2232979 + 462 WP_010969659.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DU99_RS10700 2233385..2233843 + 459 WP_038439089.1 SMI1/KNR4 family protein -
DU99_RS32510 2233878..2234048 - 171 WP_144245252.1 hypothetical protein -
DU99_RS10705 2234127..2235182 + 1056 WP_017275254.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
DU99_RS10710 2235409..2235833 - 425 Protein_2096 ATP-dependent DNA ligase -
DU99_RS36110 2235926..2236096 + 171 WP_015007719.1 hypothetical protein -
DU99_RS10715 2236089..2236457 + 369 WP_038439091.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6971.15 Da        Isoelectric Point: 11.0889

>T48448 WP_003530010.1 NZ_CP009144:2232325-2232513 [Sinorhizobium meliloti]
MKSGDIIAALQKDGWYEVATKGSHVQFKHPKKHGRVTVPHPKRDLPIGTLRSIEKQSGLKLR

Download         Length: 189 bp

>T48448 NZ_CP009144:2232325-2232513 [Sinorhizobium meliloti]
ATGAAGAGCGGCGACATTATTGCAGCATTGCAGAAGGACGGATGGTACGAGGTTGCGACCAAGGGCAGCCACGTTCAATT
CAAACATCCGAAAAAGCACGGCCGGGTTACCGTTCCTCACCCGAAGAGGGATCTACCAATCGGTACCCTCAGGAGCATTG
AAAAGCAGTCCGGTTTGAAATTGAGGTAA

Antitoxin


Download         Length: 154 a.a.        Molecular weight: 16293.17 Da        Isoelectric Point: 4.3990

>AT48448 WP_010969659.1 NZ_CP009144:2232518-2232979 [Sinorhizobium meliloti]
MRNYIGLIHKDAESDYGVSFPDFSGVVTAGADLDDARAMAEEALALHIEGLVEDGEAIPEPSSLEVVMSDAENRDCVAIL
VAVKTEAKRAIRVNVTLPEGVLKQIDAFAEAHGLTRSGFLARAATHEIERANDGHDAYAESRLSALGTSSKNV

Download         Length: 462 bp

>AT48448 NZ_CP009144:2232518-2232979 [Sinorhizobium meliloti]
ATGCGCAACTATATCGGATTGATCCACAAGGACGCCGAGAGCGATTACGGCGTTTCCTTTCCTGATTTTTCCGGCGTCGT
GACCGCCGGTGCCGACCTCGACGACGCGCGCGCTATGGCAGAGGAAGCCTTGGCCTTGCATATTGAAGGGCTGGTAGAGG
ACGGCGAGGCCATCCCGGAGCCCTCCTCCCTTGAGGTTGTCATGTCCGACGCCGAGAACAGGGATTGCGTCGCTATTCTC
GTCGCGGTGAAAACCGAGGCAAAAAGAGCCATTCGAGTGAACGTTACGCTTCCCGAAGGTGTCCTGAAGCAGATAGATGC
CTTCGCCGAAGCCCACGGCCTTACGCGGTCTGGATTTCTTGCTCGTGCTGCAACGCACGAGATCGAACGGGCAAATGACG
GCCACGACGCCTATGCGGAATCCCGCTTGTCGGCTTTGGGCACTTCCAGCAAAAATGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H0G1A3

Antitoxin

Source ID Structure
AlphaFold DB Q92NX0

References