Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 414633..415272 Replicon chromosome
Accession NZ_CP009129
Organism Planococcus sp. PAMC 21323

Toxin (Protein)


Gene name pemK Uniprot ID E7RK71
Locus tag PLANO_RS02185 Protein ID WP_008432415.1
Coordinates 414922..415272 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID E7RK70
Locus tag PLANO_RS02180 Protein ID WP_008432414.1
Coordinates 414633..414917 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PLANO_RS02155 410355..410834 + 480 WP_038702589.1 PH domain-containing protein -
PLANO_RS02160 410827..412338 + 1512 WP_038705341.1 PH domain-containing protein -
PLANO_RS02165 412386..412994 - 609 WP_038702591.1 rhomboid family intramembrane serine protease -
PLANO_RS02170 413063..413416 + 354 WP_038702593.1 holo-ACP synthase -
PLANO_RS02175 413432..414589 + 1158 WP_038702595.1 alanine racemase -
PLANO_RS02180 414633..414917 + 285 WP_008432414.1 hypothetical protein Antitoxin
PLANO_RS02185 414922..415272 + 351 WP_008432415.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PLANO_RS02190 415438..416265 + 828 WP_038702597.1 STAS domain-containing protein -
PLANO_RS02195 416262..416627 + 366 WP_186760007.1 STAS domain-containing protein -
PLANO_RS02200 416630..417031 + 402 WP_038702599.1 anti-sigma regulatory factor -
PLANO_RS02205 417044..418045 + 1002 WP_038702601.1 PP2C family protein-serine/threonine phosphatase -
PLANO_RS02210 418142..418471 + 330 WP_038702603.1 anti-sigma factor antagonist -
PLANO_RS02215 418473..418943 + 471 WP_038702606.1 anti-sigma B factor RsbW -
PLANO_RS02220 418921..419703 + 783 WP_038702608.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12880.97 Da        Isoelectric Point: 5.8817

>T48443 WP_008432415.1 NZ_CP009129:414922-415272 [Planococcus sp. PAMC 21323]
MIVKRGDVFFAELSPVVGSEQGGTRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEINAKKYGFERDSVILLEQL
RTIDKSRLTDKITQLDDTLMEKVDEALEISVGLVKF

Download         Length: 351 bp

>T48443 NZ_CP009129:414922-415272 [Planococcus sp. PAMC 21323]
TTGATTGTAAAACGCGGAGATGTTTTTTTTGCGGAATTATCGCCAGTCGTCGGGTCTGAGCAAGGTGGGACCCGTCCTGT
TCTGGTGATTCAAAACGATATAGGGAATCGTTTCAGTCCGACCGTCATTATTGCTGCAATAACGGCGCAAATTCAAAAAG
CTAAATTGCCGACACACGTAGAAATCAATGCCAAGAAATATGGTTTTGAGCGTGATTCCGTTATTTTGCTTGAACAATTA
CGAACGATTGACAAGTCAAGGTTGACCGACAAAATTACTCAACTTGACGATACATTGATGGAAAAAGTGGATGAAGCATT
GGAAATCAGTGTGGGCCTAGTAAAATTTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10689.03 Da        Isoelectric Point: 6.6344

>AT48443 WP_008432414.1 NZ_CP009129:414633-414917 [Planococcus sp. PAMC 21323]
VYGKSKTKEVVVKMPKQFISELTTHSNEHVQESGDYIYVSTNRVTKNLYDSYHIREAMIKGYVEMSQINLSIACECSHAE
YEAEHTTVRLVSGG

Download         Length: 285 bp

>AT48443 NZ_CP009129:414633-414917 [Planococcus sp. PAMC 21323]
GTGTACGGTAAGTCAAAGACAAAAGAAGTGGTTGTGAAAATGCCAAAGCAATTTATTTCGGAGTTGACAACTCATTCAAA
TGAGCATGTCCAGGAAAGTGGAGATTATATATACGTTTCCACAAACCGGGTGACGAAAAATCTGTACGACTCATATCATA
TTCGGGAAGCAATGATCAAGGGCTATGTGGAGATGTCACAAATCAATCTATCGATTGCTTGTGAATGTTCTCACGCTGAG
TACGAAGCGGAGCATACGACTGTGCGACTCGTAAGCGGAGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C7DUM1

Antitoxin

Source ID Structure
AlphaFold DB E7RK70

References