Detailed information of TA system TA048433

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 807290..807815
• Replicon: chromosome
• Accession: NZ_CP009125
• Organism: Pectobacterium atrosepticum strain 21A

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GZ59_RS03590
• Protein ID: WP_039290137.1
• Coordinates: 807290..807574 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C6D956
• Locus tag: GZ59_RS03595
• Protein ID: WP_005973616.1
• Coordinates: 807564..807815 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GZ59_RS03565	802622..803083	-	462	Protein_689	hypothetical protein	-
GZ59_RS22395	803938..804570	-	633	WP_158296417.1	transglycosylase domain-containing protein	-
GZ59_RS23645	804507..805127	-	621	WP_158296418.1	hypothetical protein	-
GZ59_RS23235	805430..805809	-	380	Protein_692	winged helix-turn-helix domain-containing protein	-
GZ59_RS03580	806233..806778	+	546	WP_039282029.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
GZ59_RS03585	806762..806962	+	201	Protein_694	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
GZ59_RS03590	807290..807574	-	285	WP_039290137.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GZ59_RS03595	807564..807815	-	252	WP_005973616.1	prevent-host-death protein	Antitoxin
GZ59_RS03600	808075..810402	-	2328	WP_039290139.1	toprim domain-containing protein	-
GZ59_RS03605	810413..810754	-	342	WP_039290142.1	DUF5375 family protein	-
GZ59_RS03610	810751..811017	-	267	WP_039290145.1	hypothetical protein	-
GZ59_RS03615	811014..811208	-	195	WP_039294697.1	hypothetical protein	-
GZ59_RS23395	811201..811398	-	198	WP_039294701.1	host cell division inhibitor Icd-like protein	-
GZ59_RS22585	811377..811745	-	369	Protein_702	ash family protein	-
GZ59_RS03630	811754..811978	-	225	WP_039281995.1	hypothetical protein	-
GZ59_RS03635	811975..812235	-	261	WP_039290147.1	AlpA family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	794178..871022	76844

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10907.88 Da
• Isoelectric Point: 10.1988

>T48433 WP_039290137.1 NZ_CP009125:c807574-807290 [Pectobacterium atrosepticum]
MSYKLEFEEHALKEFKKLGAPVRELFTKKLKAVLQNPHVPANRLHGMADCYKIKLRSAGYRLVYQVLEHEIVVLVLAVGK
RERSEVYQAAKDRL

Nucleotide

• Length: 285 bp

>T48433 NZ_CP009125:c807574-807290 [Pectobacterium atrosepticum]
ATGAGTTATAAGCTGGAGTTTGAAGAGCACGCGCTGAAAGAATTTAAGAAGCTGGGTGCACCCGTGCGGGAGCTGTTCAC
CAAAAAGCTGAAAGCGGTTTTACAAAATCCCCACGTTCCCGCCAACCGACTTCATGGAATGGCTGACTGCTACAAAATCA
AACTTCGTTCCGCTGGCTATCGGCTAGTGTATCAAGTGCTTGAGCATGAGATCGTAGTACTGGTTTTAGCTGTGGGCAAG
CGTGAACGCTCAGAGGTTTATCAAGCAGCCAAAGACCGACTATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9079.35 Da
• Isoelectric Point: 5.0807

>AT48433 WP_005973616.1 NZ_CP009125:c807815-807564 [Pectobacterium atrosepticum]
MSVQPILANAAVSISDFKKSPNAALKEANGEPVAVLTNGRISGYYVSPETWEALADYQEDIELAKIARSRMKGKRVKVDL
DEL

Nucleotide

• Length: 252 bp

>AT48433 NZ_CP009125:c807815-807564 [Pectobacterium atrosepticum]
ATGTCCGTGCAACCTATTCTTGCCAATGCTGCCGTGAGTATTAGCGACTTTAAAAAATCGCCCAATGCAGCGTTGAAAGA
AGCTAACGGCGAGCCTGTAGCCGTGTTAACCAATGGCCGTATCTCTGGCTATTATGTTTCCCCGGAAACATGGGAAGCGC
TGGCCGACTATCAGGAAGATATCGAACTTGCCAAAATTGCCCGCTCCCGGATGAAGGGGAAACGTGTGAAGGTCGATCTG
GATGAGTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A0G4JQP6