48426

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 785854..786375 Replicon chromosome
Accession NZ_CP009120
Organism Staphylococcus pseudintermedius strain 5912

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag SPS5912_RS03475 Protein ID WP_014613364.1
Coordinates 786154..786375 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag SPS5912_RS03470 Protein ID WP_014613363.1
Coordinates 785854..786141 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPS5912_RS03445 781115..781918 + 804 WP_014613358.1 hydroxyethylthiazole kinase -
SPS5912_RS03450 781908..782546 + 639 WP_014613359.1 thiamine phosphate synthase -
SPS5912_RS03455 782635..783501 + 867 WP_014613360.1 membrane protein insertase YidC -
SPS5912_RS03460 783555..784211 - 657 WP_014613361.1 HD domain-containing protein -
SPS5912_RS03465 784232..785722 - 1491 WP_014613362.1 cardiolipin synthase -
SPS5912_RS03470 785854..786141 + 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
SPS5912_RS03475 786154..786375 + 222 WP_014613364.1 heavy-metal-associated domain-containing protein Toxin
SPS5912_RS03480 786379..786585 + 207 WP_014613365.1 cation transporter -
SPS5912_RS03485 786686..788866 + 2181 WP_014613366.1 heavy metal translocating P-type ATPase -
SPS5912_RS12015 788952..789098 + 147 WP_014613367.1 hypothetical protein -
SPS5912_RS03495 790217..790945 + 729 WP_014613368.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T48426 WP_014613364.1 NZ_CP009120:786154-786375 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

>T48426 NZ_CP009120:786154-786375 [Staphylococcus pseudintermedius]
ATGGAAAATGGTTATGTTAAAGTAACACAACTGACAACTGAAGCACAGCAACAACAGCTATCTGATCGTTTGCTTCGTTT
AATTGGTGTCGAGTCTGTTGCTATTGATGTGGCAACACAATCGTTGACGCTCACTTATGACACGCCAGCAAATTTGAACA
CGATAGAAAAAGAAATTTATGATGCAGGATTTCCTGTTATCCAATCACATAAAGGAGTGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT48426 WP_014613363.1 NZ_CP009120:785854-786141 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT48426 NZ_CP009120:785854-786141 [Staphylococcus pseudintermedius]
ATGACTGAACAAGCACATCATTCTGAAGAAATTAAACGTAACTTGAAGTCGCGTTTGAATCGTATTGAAGGCCAAGTGAA
AGCAATCAACCGAATGATTGACGAAGATGTCTATTGTGATGACGTGTTGACGCAAATTAGAGCGACACGTTCGGCTTTAA
ACAGTGTGGCGTCGCGTCTGTTAGATCATCATATGAAAGGATGCATCAAGCATAAGATTGACGCGGGACACCAAGACGAA
GCGATGGAAGAGTTATTAGTAACATTTCAAAAACTCATGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References