Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2307666..2308304 Replicon chromosome
Accession NZ_CP009106
Organism Escherichia coli strain 94-3024

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag HW43_RS11420 Protein ID WP_000813794.1
Coordinates 2307666..2307842 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HW43_RS11425 Protein ID WP_001270286.1
Coordinates 2307888..2308304 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW43_RS11400 2303285..2304499 - 1215 WP_071883264.1 BenE family transporter YdcO -
HW43_RS11405 2304552..2305088 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
HW43_RS11410 2305161..2307122 + 1962 WP_021293044.1 23S rRNA 5-hydroxycytidine C2501 synthase -
HW43_RS11415 2307214..2307444 - 231 WP_000494244.1 YncJ family protein -
HW43_RS11420 2307666..2307842 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
HW43_RS11425 2307888..2308304 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
HW43_RS11430 2308383..2309789 + 1407 WP_021293381.1 PLP-dependent aminotransferase family protein -
HW43_RS11435 2310034..2311179 + 1146 WP_000047456.1 ABC transporter substrate-binding protein -
HW43_RS11440 2311197..2312210 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
HW43_RS11445 2312211..2313152 + 942 WP_001251313.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2301980..2303245 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T48386 WP_000813794.1 NZ_CP009106:2307666-2307842 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T48386 NZ_CP009106:2307666-2307842 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT48386 WP_001270286.1 NZ_CP009106:2307888-2308304 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT48386 NZ_CP009106:2307888-2308304 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CACTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References