Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 18245..18767 | Replicon | plasmid pSTY1 |
| Accession | NZ_CP009103 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 13311 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G3CAN5 |
| Locus tag | IZ85_RS23200 | Protein ID | WP_000220560.1 |
| Coordinates | 18245..18526 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G3CAG1 |
| Locus tag | IZ85_RS23205 | Protein ID | WP_000121743.1 |
| Coordinates | 18516..18767 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IZ85_RS23165 | 14090..15256 | - | 1167 | WP_025840297.1 | relaxase/mobilization nuclease domain-containing protein | - |
| IZ85_RS23170 | 15259..15804 | - | 546 | WP_000757692.1 | hypothetical protein | - |
| IZ85_RS25680 | 15799..15873 | - | 75 | Protein_18 | DNA distortion polypeptide 3 | - |
| IZ85_RS24880 | 16130..16402 | - | 273 | WP_000160399.1 | hypothetical protein | - |
| IZ85_RS25685 | 16415..16564 | - | 150 | WP_000003880.1 | hypothetical protein | - |
| IZ85_RS24885 | 16634..16813 | - | 180 | WP_071881863.1 | hypothetical protein | - |
| IZ85_RS23180 | 16856..17185 | - | 330 | WP_000866645.1 | hypothetical protein | - |
| IZ85_RS23185 | 17278..17493 | - | 216 | WP_001180117.1 | hypothetical protein | - |
| IZ85_RS23190 | 17483..17728 | - | 246 | WP_025840296.1 | hypothetical protein | - |
| IZ85_RS23195 | 17776..18099 | - | 324 | WP_025840295.1 | hypothetical protein | - |
| IZ85_RS23200 | 18245..18526 | - | 282 | WP_000220560.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| IZ85_RS23205 | 18516..18767 | - | 252 | WP_000121743.1 | plasmid stabilization protein | Antitoxin |
| IZ85_RS23210 | 19829..20683 | + | 855 | WP_001239324.1 | replication initiation protein | - |
| IZ85_RS23215 | 20708..21154 | + | 447 | WP_025840294.1 | hypothetical protein | - |
| IZ85_RS23220 | 21222..21647 | + | 426 | WP_106372024.1 | DNA distortion polypeptide 3 | - |
| IZ85_RS25690 | 21699..21932 | - | 234 | WP_144077445.1 | YcxB family protein | - |
| IZ85_RS25695 | 22110..22295 | - | 186 | Protein_32 | YcxB family protein | - |
| IZ85_RS25700 | 22730..23041 | - | 312 | WP_001423339.1 | hypothetical protein | - |
| IZ85_RS23240 | 23057..23287 | - | 231 | WP_000051063.1 | partitioning protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..38457 | 38457 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 13852.62 Da Isoelectric Point: 5.5500
>T48355 WP_000220560.1 NZ_CP009103:c18526-18245 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
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FFFFFFFFFFFFFF
Download Length: 282 bp
>T48355 NZ_CP009103:c18526-18245 [Salmonella enterica subsp. enterica serovar Typhimurium]
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Antitoxin
Download Length: 84 a.a. Molecular weight: 12380.85 Da Isoelectric Point: 5.5500
>AT48355 WP_000121743.1 NZ_CP009103:c18767-18516 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
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Download Length: 252 bp
>AT48355 NZ_CP009103:c18767-18516 [Salmonella enterica subsp. enterica serovar Typhimurium]
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Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G3CAN5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3S5I301 |