Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3707640..3708314 Replicon chromosome
Accession NZ_CP009100
Organism Mycobacterium tuberculosis strain ZMC13-264

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag IZ84_RS17530 Protein ID WP_003417282.1
Coordinates 3707640..3708068 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag IZ84_RS17535 Protein ID WP_003417286.1
Coordinates 3708072..3708314 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IZ84_RS17505 3703462..3703863 - 402 WP_003417264.1 cytidine deaminase -
IZ84_RS17510 3704004..3704438 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
IZ84_RS17515 3704435..3704869 + 435 WP_038435985.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
IZ84_RS17520 3704998..3706770 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
IZ84_RS17525 3706770..3707561 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
IZ84_RS17530 3707640..3708068 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
IZ84_RS17535 3708072..3708314 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
IZ84_RS17540 3708436..3709050 - 615 WP_038435986.1 class I SAM-dependent methyltransferase -
IZ84_RS17545 3709047..3709712 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
IZ84_RS17550 3709713..3710246 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
IZ84_RS22315 3710243..3710332 - 90 WP_009934953.1 pterin-4-alpha-carbinolamine dehydratase moaB3 -
IZ84_RS17565 3710431..3711692 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T48291 WP_003417282.1 NZ_CP009100:c3708068-3707640 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T48291 NZ_CP009100:c3708068-3707640 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT48291 WP_003417286.1 NZ_CP009100:c3708314-3708072 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT48291 NZ_CP009100:c3708314-3708072 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References