Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2930081..2930795 Replicon chromosome
Accession NZ_CP009100
Organism Mycobacterium tuberculosis strain ZMC13-264

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag IZ84_RS13745 Protein ID WP_003413460.1
Coordinates 2930355..2930795 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag IZ84_RS13740 Protein ID WP_003413456.1
Coordinates 2930081..2930368 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IZ84_RS13705 2925504..2925749 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
IZ84_RS13710 2925746..2926150 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
IZ84_RS13715 2926367..2926987 + 621 WP_003912795.1 DUF4178 domain-containing protein -
IZ84_RS13720 2926998..2927492 + 495 WP_003413444.1 DUF2617 family protein -
IZ84_RS13725 2927489..2927920 + 432 WP_003899390.1 DUF4247 domain-containing protein -
IZ84_RS13730 2927945..2928403 + 459 WP_003413451.1 DUF350 domain-containing protein -
IZ84_RS13735 2928400..2929970 + 1571 Protein_2685 polyamine aminopropyltransferase -
IZ84_RS13740 2930081..2930368 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
IZ84_RS13745 2930355..2930795 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
IZ84_RS13750 2930816..2931571 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
IZ84_RS13755 2931704..2932300 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
IZ84_RS13760 2932308..2933153 - 846 WP_003413466.1 acyl-CoA thioesterase II -
IZ84_RS13765 2933182..2934081 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
IZ84_RS13770 2934209..2934883 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T48281 WP_003413460.1 NZ_CP009100:2930355-2930795 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T48281 NZ_CP009100:2930355-2930795 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT48281 WP_003413456.1 NZ_CP009100:2930081-2930368 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT48281 NZ_CP009100:2930081-2930368 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References