Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2225410..2226098 Replicon chromosome
Accession NZ_CP009100
Organism Mycobacterium tuberculosis strain ZMC13-264

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag IZ84_RS10380 Protein ID WP_003409958.1
Coordinates 2225410..2225829 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag IZ84_RS10385 Protein ID WP_003409968.1
Coordinates 2225838..2226098 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IZ84_RS10360 2220905..2221753 + 849 WP_003901306.1 class I SAM-dependent methyltransferase -
IZ84_RS10365 2221716..2223161 - 1446 WP_003899115.1 APC family permease -
IZ84_RS10370 2223340..2224026 - 687 WP_038435903.1 immunoprotective protein Mpt64 -
IZ84_RS10375 2224217..2225185 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
IZ84_RS10380 2225410..2225829 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
IZ84_RS10385 2225838..2226098 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IZ84_RS10390 2226241..2227917 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
IZ84_RS10395 2227905..2228558 - 654 WP_003409976.1 cutinase Cfp21 -
IZ84_RS10400 2228673..2228903 + 231 WP_003409980.1 DUF167 domain-containing protein -
IZ84_RS10405 2228988..2229899 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
IZ84_RS10410 2230008..2230607 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T48268 WP_003409958.1 NZ_CP009100:c2225829-2225410 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T48268 NZ_CP009100:c2225829-2225410 [Mycobacterium tuberculosis]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT48268 WP_003409968.1 NZ_CP009100:c2226098-2225838 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT48268 NZ_CP009100:c2226098-2225838 [Mycobacterium tuberculosis]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References