Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 710805..711430 Replicon chromosome
Accession NZ_CP009100
Organism Mycobacterium tuberculosis strain ZMC13-264

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag IZ84_RS03220 Protein ID WP_003403218.1
Coordinates 711029..711430 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag IZ84_RS03215 Protein ID WP_003403213.1
Coordinates 710805..711032 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IZ84_RS03185 705984..706205 - 222 WP_003898525.1 DUF4926 domain-containing protein -
IZ84_RS03190 706347..706952 + 606 WP_003898526.1 hypothetical protein -
IZ84_RS03195 706971..709538 - 2568 WP_003901879.1 SEC-C domain-containing protein -
IZ84_RS03200 709622..710371 + 750 WP_003898528.1 hypothetical protein -
IZ84_RS03205 710368..710610 + 243 WP_003403210.1 hypothetical protein -
IZ84_RS03215 710805..711032 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
IZ84_RS03220 711029..711430 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
IZ84_RS20850 711559..712254 + 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
IZ84_RS20855 712251..712742 + 492 WP_003905354.1 galactose-1-phosphate uridylyltransferase -
IZ84_RS03230 712739..713830 + 1092 WP_003900977.1 galactokinase -
IZ84_RS03235 714224..715288 + 1065 WP_003898532.1 hypothetical protein -
IZ84_RS03240 715392..716339 + 948 WP_016810166.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T48245 WP_003403218.1 NZ_CP009100:711029-711430 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T48245 NZ_CP009100:711029-711430 [Mycobacterium tuberculosis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT48245 WP_003403213.1 NZ_CP009100:710805-711032 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT48245 NZ_CP009100:710805-711032 [Mycobacterium tuberculosis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References