Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5026709..5027540 Replicon chromosome
Accession NZ_CP009072
Organism Escherichia coli ATCC 25922

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag DR76_RS24935 Protein ID WP_000854814.1
Coordinates 5027166..5027540 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag DR76_RS24930 Protein ID WP_001285586.1
Coordinates 5026709..5027077 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DR76_RS24895 5021926..5022996 + 1071 WP_000102631.1 patatin-like phospholipase family protein -
DR76_RS24900 5023132..5023809 + 678 WP_001362823.1 hypothetical protein -
DR76_RS24905 5023825..5024235 + 411 WP_000846704.1 hypothetical protein -
DR76_RS24910 5024456..5025277 + 822 WP_001234569.1 DUF945 domain-containing protein -
DR76_RS24915 5025368..5025853 + 486 WP_000213703.1 antirestriction protein -
DR76_RS24920 5025869..5026345 + 477 WP_001351157.1 RadC family protein -
DR76_RS24925 5026414..5026635 + 222 WP_000692323.1 DUF987 domain-containing protein -
DR76_RS24930 5026709..5027077 + 369 WP_001285586.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
DR76_RS24935 5027166..5027540 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
DR76_RS24940 5027537..5027731 + 195 WP_000988601.1 hypothetical protein -
DR76_RS29595 5027744..5027857 + 114 WP_001161660.1 DUF957 domain-containing protein -
DR76_RS29395 5028146..5028319 - 174 WP_032082634.1 transposase domain-containing protein -
DR76_RS29400 5028346..5028528 + 183 WP_001016348.1 hypothetical protein -
DR76_RS24955 5028629..5028958 - 330 WP_000450409.1 DUF496 family protein -
DR76_RS24960 5029130..5030188 - 1059 WP_001200890.1 FUSC family protein -
DR76_RS24965 5030386..5030859 - 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
DR76_RS28810 5030916..5032134 - 1219 Protein_4696 ISL3-like element ISEc53 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T48231 WP_000854814.1 NZ_CP009072:5027166-5027540 [Escherichia coli ATCC 25922]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T48231 NZ_CP009072:5027166-5027540 [Escherichia coli ATCC 25922]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT48231 WP_001285586.1 NZ_CP009072:5026709-5027077 [Escherichia coli ATCC 25922]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT48231 NZ_CP009072:5026709-5027077 [Escherichia coli ATCC 25922]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References