Detailed information of TA system TA048212

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 2571884..2572704
• Replicon: chromosome
• Accession: NZ_CP009072
• Organism: Escherichia coli ATCC 25922

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: DR76_RS12500
• Protein ID: WP_001054379.1
• Coordinates: 2572447..2572704 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: DR76_RS12495
• Protein ID: WP_000123957.1
• Coordinates: 2571884..2572435 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DR76_RS12470	2567578..2568891	-	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-
DR76_RS12475	2568903..2569181	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
DR76_RS12480	2569178..2570299	-	1122	WP_000010833.1	M42 family metallopeptidase	-
DR76_RS29625	2570544..2570660	-	117	Protein_2337	VOC family protein	-
DR76_RS12485	2570698..2570958	-	261	WP_000077645.1	hypothetical protein	-
DR76_RS12490	2571086..2571832	-	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
DR76_RS12495	2571884..2572435	-	552	WP_000123957.1	N-acetyltransferase	Antitoxin
DR76_RS12500	2572447..2572704	-	258	WP_001054379.1	YjhX family toxin	Toxin
DR76_RS26900	2573081..2573245	-	165	Protein_2342	GNAT family N-acetyltransferase	-
DR76_RS28360	2573278..2574427	-	1150	Protein_2343	IS3 family transposase	-
DR76_RS12515	2574490..2575596	+	1107	Protein_2344	helicase YjhR	-
DR76_RS12520	2576179..2577159	-	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T48212 WP_001054379.1 NZ_CP009072:c2572704-2572447 [Escherichia coli ATCC 25922]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T48212 NZ_CP009072:c2572704-2572447 [Escherichia coli ATCC 25922]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT48212 WP_000123957.1 NZ_CP009072:c2572435-2571884 [Escherichia coli ATCC 25922]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT48212 NZ_CP009072:c2572435-2571884 [Escherichia coli ATCC 25922]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: B6I030