Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 5378..5937 Replicon plasmid p15648-3
Accession NZ_CP009053
Organism Escherichia coli NCCP15648

Toxin (Protein)


Gene name relE Uniprot ID G4VUF8
Locus tag A610_RS29405 Protein ID WP_000421273.1
Coordinates 5378..5653 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SRR3
Locus tag A610_RS29410 Protein ID WP_001387467.1
Coordinates 5653..5937 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A610_RS29365 1428..2168 - 741 WP_001388582.1 tyrosine-type recombinase/integrase -
A610_RS29370 2289..2471 - 183 WP_048657295.1 hypothetical protein -
A610_RS29380 2815..3122 - 308 Protein_3 type II toxin-antitoxin system ParD family antitoxin -
A610_RS29390 3615..4783 + 1169 Protein_4 hypothetical protein -
A610_RS29395 4816..4944 + 129 Protein_5 IS481 family transposase -
A610_RS29400 4979..5272 - 294 WP_001105065.1 hypothetical protein -
A610_RS29405 5378..5653 - 276 WP_000421273.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A610_RS29410 5653..5937 - 285 WP_001387467.1 ribbon-helix-helix domain-containing protein Antitoxin
A610_RS29425 6854..7876 - 1023 WP_000234918.1 replication initiation protein -
A610_RS29430 7866..8399 - 534 WP_001505108.1 incFII RepA family protein -
A610_RS29435 8392..8466 - 75 WP_001388587.1 RepA leader peptide Tap -
A610_RS29445 8699..8956 - 258 WP_000083826.1 replication regulatory protein RepA -
A610_RS29450 9196..9786 - 591 WP_000766804.1 DUF2726 domain-containing protein -
A610_RS29455 9825..10034 - 210 Protein_14 hemolysin expression modulator Hha -
A610_RS29460 10080..10541 - 462 WP_001233835.1 thermonuclease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid blaTEM-1B pic / aap/aspU / agg3A / agg3B / agg3C / agg3D 1..78111 78111


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10765.45 Da        Isoelectric Point: 9.9324

>T48198 WP_000421273.1 NZ_CP009053:c5653-5378 [Escherichia coli NCCP15648]
MELKWTSKALSDLSRLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYEINGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T48198 NZ_CP009053:c5653-5378 [Escherichia coli NCCP15648]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGTCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAAATTAATGGCCAGACTATTTAT
GTATTGCGTCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10460.87 Da        Isoelectric Point: 5.6558

>AT48198 WP_001387467.1 NZ_CP009053:c5937-5653 [Escherichia coli NCCP15648]
MQMKNNAAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
SDSLSTDNPLPVPR

Download         Length: 285 bp

>AT48198 NZ_CP009053:c5937-5653 [Escherichia coli NCCP15648]
ATGCAAATGAAAAACAATGCCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGTTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
TCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y6H1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y880

References