Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 2630..3177 Replicon plasmid p15648-2
Accession NZ_CP009052
Organism Escherichia coli NCCP15648

Toxin (Protein)


Gene name parE Uniprot ID A0A896ZGX1
Locus tag A610_RS28810 Protein ID WP_000969997.1
Coordinates 2896..3177 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E0WH52
Locus tag A610_RS28805 Protein ID WP_000079932.1
Coordinates 2630..2899 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A610_RS28790 688..1719 + 1032 WP_000907881.1 replication initiation protein -
A610_RS30330 2417..2575 + 159 WP_000829588.1 hypothetical protein -
A610_RS28805 2630..2899 + 270 WP_000079932.1 hypothetical protein Antitoxin
A610_RS28810 2896..3177 + 282 WP_000969997.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A610_RS28815 3373..3714 - 342 WP_000578011.1 hypothetical protein -
A610_RS28820 4014..4601 + 588 WP_001418189.1 serine acetyltransferase -
A610_RS28825 4883..5476 - 594 WP_001401779.1 hypothetical protein -
A610_RS28835 5830..7176 + 1347 WP_001132021.1 hypothetical protein -
A610_RS30335 7687..7989 - 303 WP_001245884.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..83860 83860


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10879.54 Da        Isoelectric Point: 8.4615

>T48197 WP_000969997.1 NZ_CP009052:2896-3177 [Escherichia coli NCCP15648]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YVLRVLHTAQKWP

Download         Length: 282 bp

>T48197 NZ_CP009052:2896-3177 [Escherichia coli NCCP15648]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGTCGCAACGGTC
GTGTGGAAGGAACCCGGGAACTGGTTATTCACCCCCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATGTCCTGCGCGTGTTGCATACCGCACAGAAGTGGCCATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10268.58 Da        Isoelectric Point: 7.2055

>AT48197 WP_000079932.1 NZ_CP009052:2630-2899 [Escherichia coli NCCP15648]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVSDK

Download         Length: 270 bp

>AT48197 NZ_CP009052:2630-2899 [Escherichia coli NCCP15648]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCTGCCGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTTCCGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A896ZGX1

Antitoxin

Source ID Structure
AlphaFold DB A0A5U8RN22

References