Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1336925..1337723 Replicon chromosome
Accession NZ_CP009050
Organism Escherichia coli NCCP15648

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3L4GA68
Locus tag A610_RS06975 Protein ID WP_000854898.1
Coordinates 1337346..1337723 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3L4GA79
Locus tag A610_RS06970 Protein ID WP_001390639.1
Coordinates 1336925..1337299 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A610_RS06925 1332433..1332891 + 459 WP_000771527.1 hypothetical protein -
A610_RS06930 1333017..1333556 + 540 WP_001104026.1 DUF4339 domain-containing protein -
A610_RS06935 1333826..1334239 + 414 WP_000789536.1 hypothetical protein -
A610_RS30045 1334378..1334556 - 179 Protein_1263 hypothetical protein -
A610_RS06950 1334650..1335468 + 819 WP_001234635.1 DUF945 domain-containing protein -
A610_RS06955 1335560..1336045 + 486 WP_000213691.1 antirestriction protein -
A610_RS06960 1336061..1336537 + 477 WP_001186776.1 RadC family protein -
A610_RS06965 1336624..1336845 + 222 WP_000692352.1 DUF987 domain-containing protein -
A610_RS06970 1336925..1337299 + 375 WP_001390639.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
A610_RS06975 1337346..1337723 + 378 WP_000854898.1 TA system toxin CbtA family protein Toxin
A610_RS06980 1337720..1338208 + 489 WP_000761668.1 hypothetical protein -
A610_RS06985 1338220..1338417 + 198 WP_000839285.1 DUF957 domain-containing protein -
A610_RS06990 1338514..1339356 + 843 WP_000014507.1 DUF4942 domain-containing protein -
A610_RS07000 1339827..1340765 + 939 WP_000351313.1 glyoxylate/hydroxypyruvate reductase GhrA -
A610_RS07005 1340820..1341557 + 738 WP_000283664.1 zinc-binding phosphatase -
A610_RS07010 1341581..1342135 + 555 WP_001001902.1 molecular chaperone YcdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14050.07 Da        Isoelectric Point: 8.5190

>T48176 WP_000854898.1 NZ_CP009050:1337346-1337723 [Escherichia coli NCCP15648]
MKTLSDTHVREVSRCPSPVTIWKTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITLGKHPEAKQ

Download         Length: 378 bp

>T48176 NZ_CP009050:1337346-1337723 [Escherichia coli NCCP15648]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGAAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGAATTTCACTGTGTGATGCAGTGAATTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13566.36 Da        Isoelectric Point: 6.0568

>AT48176 WP_001390639.1 NZ_CP009050:1336925-1337299 [Escherichia coli NCCP15648]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTATLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT48176 NZ_CP009050:1336925-1337299 [Escherichia coli NCCP15648]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGCTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCAGGT
TCAGCGACGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCGGCGGT
GAACTGAATCCCCGACATCAGCATACCGCCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCACCCGCAACCACTTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L4GA68

Antitoxin

Source ID Structure
AlphaFold DB A0A3L4GA79

References