Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 4301935..4303628 Replicon chromosome
Accession NZ_CP009048
Organism Pseudomonas alkylphenolica strain KL28

Toxin (Protein)


Gene name doc Uniprot ID A0A077FF08
Locus tag PSAKL28_RS19710 Protein ID WP_038613650.1
Coordinates 4301935..4302804 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A077FIL4
Locus tag PSAKL28_RS19715 Protein ID WP_038613652.1
Coordinates 4302801..4303628 (+) Length 276 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSAKL28_RS19685 4297918..4298769 + 852 WP_038613642.1 ABC transporter ATP-binding protein -
PSAKL28_RS19690 4298809..4299807 + 999 WP_038613644.1 ABC transporter substrate-binding protein -
PSAKL28_RS19695 4299837..4300613 + 777 WP_038613646.1 ABC transporter permease -
PSAKL28_RS19700 4300613..4301377 + 765 WP_038616883.1 SDR family oxidoreductase -
PSAKL28_RS19705 4301392..4301931 + 540 WP_038613648.1 cupin domain-containing protein -
PSAKL28_RS19710 4301935..4302804 + 870 WP_038613650.1 alpha/beta hydrolase Toxin
PSAKL28_RS19715 4302801..4303628 + 828 WP_038613652.1 IclR family transcriptional regulator Antitoxin
PSAKL28_RS19720 4303630..4304430 + 801 WP_038613654.1 SDR family oxidoreductase -
PSAKL28_RS19725 4304423..4306105 + 1683 WP_038613656.1 thiamine pyrophosphate-binding protein -
PSAKL28_RS19730 4306116..4306919 + 804 WP_038613657.1 aspartate dehydrogenase -
PSAKL28_RS19735 4306930..4308420 + 1491 WP_096335685.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-153)

Antitoxin

Transcription regulator IclR, N-terminal

(19-68)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30556.87 Da        Isoelectric Point: 7.1823

>T48171 WP_038613650.1 NZ_CP009048:4301935-4302804 [Pseudomonas alkylphenolica]
MLHATDNSLAALEAQLPQRFAQRLVQLADGAQAIREAGYGPAIVLLHGIGSGAASWLQVAVQLSQRARVIAWDAPGYGDS
SPLTASAPKAADYARRLRQLLDALQIDHCVLVGHSLGALSAAALAYQQPQRIKRLVLISPARGYGDPARAEQAQQVRSQR
LHNLEQLGIAQMASQRSAHMLSPAASAEARAWVQWNMARLIPQGYRQAIELLCGDDLLRYADLAVPCEVHCGAADSITTP
ADCQALASALGAPFHLIAAAGHASPIEQPEAVATQLARALDVSLTGTAL

Download         Length: 870 bp

>T48171 NZ_CP009048:4301935-4302804 [Pseudomonas alkylphenolica]
ATGTTGCACGCCACCGACAACTCGCTCGCCGCCCTTGAGGCACAGTTGCCACAGCGCTTCGCGCAGCGTCTGGTGCAACT
GGCCGACGGCGCCCAGGCGATCCGCGAAGCCGGGTACGGGCCTGCCATTGTGCTGCTGCATGGCATTGGCTCGGGCGCCG
CGTCCTGGCTGCAGGTGGCCGTGCAGCTGAGTCAGCGCGCCCGGGTAATCGCCTGGGATGCACCTGGCTATGGCGACTCC
AGCCCGCTGACCGCCTCTGCCCCCAAGGCCGCCGACTATGCCCGGCGCCTGCGGCAACTGCTTGATGCACTGCAGATTGA
TCACTGTGTGCTGGTCGGCCATTCCCTCGGCGCCCTCAGCGCTGCGGCCCTGGCCTACCAGCAACCGCAGCGGATCAAGC
GCCTGGTGCTGATCAGCCCGGCCCGCGGCTATGGCGACCCGGCCCGTGCCGAGCAGGCGCAGCAGGTGCGCAGCCAGCGT
CTGCACAACCTCGAGCAACTGGGTATCGCCCAGATGGCCAGCCAGCGCAGCGCGCACATGCTCTCGCCAGCGGCCAGCGC
CGAGGCCCGCGCCTGGGTGCAGTGGAACATGGCGCGCCTGATTCCCCAGGGCTATCGCCAGGCCATCGAGTTGCTCTGTG
GCGACGACCTGCTGCGCTACGCCGACCTGGCCGTGCCTTGCGAAGTGCACTGCGGCGCCGCCGACAGCATCACCACGCCA
GCCGACTGCCAGGCCCTGGCCAGCGCCCTGGGCGCGCCGTTTCACCTGATTGCCGCGGCTGGCCATGCCAGCCCGATCGA
ACAACCCGAGGCGGTGGCAACCCAGCTTGCCCGGGCCCTCGACGTCTCACTGACAGGTACTGCGCTATGA

Antitoxin


Download         Length: 276 a.a.        Molecular weight: 30353.75 Da        Isoelectric Point: 6.3865

>AT48171 WP_038613652.1 NZ_CP009048:4302801-4303628 [Pseudomonas alkylphenolica]
MNDSDLLKDNQDKYIVPGLERGLLLLCEFSRQNRTLTAPELARRLELPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLR
LGFEYLASLELTELGQPLLARLCDHLNYPSNLVVRDGRSIVYVAKVSPPSVFSSAVNVGTRLPAHATVLGRILLEDLSLA
ELRELYPEEHLEQHSPCTPKTVLELFDLVQGDRQRGYVSGEGFFEPSISTIAAPVRDHSGKVVAAMGVTIPTAQVGHINF
DGLLGHVRGNADELSRLLNYTPNAGSGRVTALMRD

Download         Length: 828 bp

>AT48171 NZ_CP009048:4302801-4303628 [Pseudomonas alkylphenolica]
ATGAATGATTCGGATCTGTTGAAGGACAACCAGGACAAGTACATCGTCCCCGGCCTTGAGCGCGGCCTGTTGCTGCTCTG
CGAGTTCAGCCGGCAAAACCGTACCCTGACCGCACCGGAACTGGCACGGCGCCTGGAGCTGCCGCGCTCGACCATCTTCC
GCCTGCTGACCACCCTGGAAACCATGGGCTTCGTCACCCGCAGCGGCAACGAATACCGCCTGGGCATGTCGGTGCTGCGC
CTGGGCTTCGAATACCTCGCCTCGCTGGAACTGACCGAGCTCGGCCAGCCGCTGCTGGCACGGCTGTGCGACCACCTCAA
CTACCCGAGCAATCTGGTGGTGCGCGATGGTCGCTCGATTGTCTATGTCGCCAAGGTCTCGCCACCCTCGGTGTTCTCCA
GTGCGGTCAACGTCGGCACCCGCCTGCCGGCTCACGCCACGGTGCTCGGGCGCATCCTCCTGGAAGACCTGAGTCTGGCC
GAGCTGCGCGAGCTGTACCCGGAAGAACACCTTGAGCAGCACTCGCCGTGCACGCCGAAAACCGTGCTGGAACTGTTCGA
CTTGGTGCAGGGCGACCGCCAGCGCGGCTATGTCAGCGGCGAAGGGTTTTTCGAGCCATCGATCTCGACCATTGCCGCCC
CGGTGCGCGATCACAGCGGCAAGGTGGTCGCCGCCATGGGCGTGACCATTCCCACAGCGCAGGTTGGCCATATCAATTTC
GACGGTTTGCTCGGTCACGTACGCGGCAACGCCGACGAACTGTCACGCCTGCTCAACTACACGCCTAACGCCGGTTCCGG
CCGCGTTACTGCCTTGATGAGGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A077FF08

Antitoxin

Source ID Structure
AlphaFold DB A0A077FIL4

References