48170

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 634205..634758 Replicon chromosome
Accession NZ_CP009048
Organism Pseudomonas alkylphenolica strain KL28

Toxin (Protein)


Gene name parE Uniprot ID A0A077F326
Locus tag PSAKL28_RS26660 Protein ID WP_075226426.1
Coordinates 634465..634758 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A077F2V7
Locus tag PSAKL28_RS02970 Protein ID WP_010487122.1
Coordinates 634205..634477 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSAKL28_RS02950 630277..631365 - 1089 WP_038606315.1 macro domain-containing protein -
PSAKL28_RS02955 631362..632006 - 645 WP_038606318.1 DUF4433 domain-containing protein -
PSAKL28_RS02960 632007..632576 - 570 WP_038606320.1 DUF4433 domain-containing protein -
PSAKL28_RS02965 632796..633707 - 912 WP_038606323.1 restriction endonuclease -
PSAKL28_RS02970 634205..634477 + 273 WP_010487122.1 CopG family ribbon-helix-helix protein Antitoxin
PSAKL28_RS26660 634465..634758 + 294 WP_075226426.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PSAKL28_RS02975 635138..636109 + 972 WP_038616202.1 inovirus-type Gp2 protein -
PSAKL28_RS02980 636252..637154 - 903 WP_038606327.1 LysR family transcriptional regulator -
PSAKL28_RS02985 637506..639125 + 1620 WP_174446955.1 DUF1302 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11131.68 Da        Isoelectric Point: 5.2448

>T48170 WP_075226426.1 NZ_CP009048:634465-634758 [Pseudomonas alkylphenolica]
VPRLIITEGAAQGLERCRQFLVEKGPQVARRAAQAIERQLARLEEGPEVGRPFPELPELRELIIEFGESGYVALYRHERE
DDAVYVLAFRHQKEVGY

Download         Length: 294 bp

>T48170 NZ_CP009048:634465-634758 [Pseudomonas alkylphenolica]
GTGCCACGATTGATTATCACTGAAGGCGCTGCGCAAGGGCTGGAGCGTTGCCGTCAGTTTCTTGTCGAGAAAGGTCCGCA
GGTAGCTCGGCGTGCTGCCCAGGCGATTGAGCGACAACTTGCTCGACTAGAAGAAGGGCCGGAAGTAGGTCGTCCATTCC
CAGAACTGCCGGAACTGCGTGAGCTGATAATCGAGTTCGGTGAGTCGGGGTATGTTGCGCTCTATCGGCATGAGCGGGAG
GATGACGCTGTATATGTACTGGCCTTTCGGCATCAGAAAGAAGTCGGTTACTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10467.64 Da        Isoelectric Point: 6.0804

>AT48170 WP_010487122.1 NZ_CP009048:634205-634477 [Pseudomonas alkylphenolica]
MATSIKIDDELKNRIQHLAGLRQRSSHWIMREAIAQYVEREEAREGFKQEALASWAAYQETGRHLTGQETRTWLNTWGTD
AEAELPKCHD

Download         Length: 273 bp

>AT48170 NZ_CP009048:634205-634477 [Pseudomonas alkylphenolica]
ATGGCCACTTCTATCAAAATTGATGACGAGCTGAAAAATCGCATTCAGCACCTAGCTGGTCTGCGTCAACGTTCGTCCCA
CTGGATTATGCGCGAAGCGATAGCGCAGTACGTCGAGCGCGAAGAGGCCCGCGAGGGCTTTAAACAGGAAGCCCTGGCTT
CGTGGGCAGCGTATCAGGAAACGGGGCGGCATCTGACCGGCCAAGAGACTCGGACCTGGCTAAATACCTGGGGCACCGAT
GCTGAGGCGGAGCTTCCCAAGTGCCACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A077F326

Antitoxin

Source ID Structure
AlphaFold DB A0A077F2V7

References