Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 338389..338908 Replicon chromosome
Accession NZ_CP009048
Organism Pseudomonas alkylphenolica strain KL28

Toxin (Protein)


Gene name relE Uniprot ID A0A077F6C2
Locus tag PSAKL28_RS01550 Protein ID WP_038605717.1
Coordinates 338618..338908 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A077F262
Locus tag PSAKL28_RS01545 Protein ID WP_038605715.1
Coordinates 338389..338628 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSAKL28_RS01530 334767..335957 + 1191 WP_038605707.1 MFS transporter -
PSAKL28_RS01535 335962..337110 - 1149 WP_038605710.1 hypothetical protein -
PSAKL28_RS01540 337285..338298 + 1014 WP_038605712.1 ADP-glyceromanno-heptose 6-epimerase -
PSAKL28_RS01545 338389..338628 + 240 WP_038605715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PSAKL28_RS01550 338618..338908 + 291 WP_038605717.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PSAKL28_RS01560 339164..339406 - 243 WP_038605719.1 hypothetical protein -
PSAKL28_RS01565 339431..339811 - 381 WP_038605721.1 hypothetical protein -
PSAKL28_RS01570 339830..340036 - 207 WP_038605723.1 helix-turn-helix transcriptional regulator -
PSAKL28_RS01575 340046..340624 - 579 WP_038605725.1 hypothetical protein -
PSAKL28_RS01580 341103..341462 + 360 WP_038605728.1 multidrug/spermidine efflux SMR transporter subunit MdtJ -
PSAKL28_RS01585 341456..341785 + 330 WP_038605730.1 multidrug/spermidine efflux SMR transporter subunit MdtI -
PSAKL28_RS01590 342025..343245 - 1221 WP_038605733.1 methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-64)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11260.08 Da        Isoelectric Point: 10.0984

>T48168 WP_038605717.1 NZ_CP009048:338618-338908 [Pseudomonas alkylphenolica]
MTYSLEFDARALKEWHKLGDTVRQQLKKKLATVLLNPRVEANRLHGLPDCYKIKLRSSGYRLVYQVIDQEVVVFVVAVDK
REREQVYRKAAERLGD

Download         Length: 291 bp

>T48168 NZ_CP009048:338618-338908 [Pseudomonas alkylphenolica]
ATGACCTATAGCCTTGAGTTTGATGCACGAGCGCTGAAGGAATGGCACAAGCTGGGAGACACCGTTCGCCAGCAGCTCAA
GAAAAAGCTGGCTACGGTTTTGCTCAACCCACGGGTTGAAGCGAACCGGCTGCATGGCTTGCCCGATTGCTACAAGATCA
AGCTGCGTAGCAGTGGCTATCGGTTGGTCTATCAGGTGATTGACCAGGAGGTCGTGGTGTTTGTGGTTGCTGTGGATAAA
CGAGAGCGGGAGCAGGTTTATCGGAAGGCGGCTGAGCGGTTAGGAGATTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8968.36 Da        Isoelectric Point: 4.8011

>AT48168 WP_038605715.1 NZ_CP009048:338389-338628 [Pseudomonas alkylphenolica]
MASINVRIDDDLKARAYRELEKLGVTPSELMRQALQYVAERGQLPFKPVLMTEDDEALLATVRERLAAPQRVKVSLDDL

Download         Length: 240 bp

>AT48168 NZ_CP009048:338389-338628 [Pseudomonas alkylphenolica]
ATGGCATCTATCAACGTACGTATCGACGACGATCTCAAAGCGCGTGCATACCGCGAACTTGAAAAGCTGGGTGTCACGCC
TTCCGAGCTGATGCGCCAAGCGCTGCAATATGTAGCAGAGCGCGGCCAGTTGCCTTTCAAGCCAGTGCTGATGACTGAGG
ATGATGAGGCTCTGCTTGCTACGGTGCGCGAACGTCTTGCTGCACCTCAGCGGGTAAAGGTCTCGCTGGATGACCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A077F6C2

Antitoxin

Source ID Structure
AlphaFold DB A0A077F262

References