48167

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 660530..661039 Replicon chromosome
Accession NZ_CP009046
Organism Staphylococcus epidermidis strain SEI

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag DP17_RS03105 Protein ID WP_001829980.1
Coordinates 660530..660739 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag DP17_RS03110 Protein ID WP_001829893.1
Coordinates 660746..661039 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DP17_RS03085 656109..657464 - 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
DP17_RS03090 657476..658549 - 1074 WP_001832735.1 D-alanine--D-alanine ligase -
DP17_RS03095 658940..660151 + 1212 WP_002486299.1 rod shape-determining protein RodA -
DP17_RS03100 660250..660387 - 138 WP_001829949.1 hypothetical protein -
DP17_RS03105 660530..660739 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
DP17_RS03110 660746..661039 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
DP17_RS03115 661213..662697 + 1485 WP_002457116.1 cardiolipin synthase -
DP17_RS03120 662879..663532 + 654 WP_001829983.1 HD domain-containing protein -
DP17_RS03125 663638..664510 - 873 WP_002458703.1 membrane protein insertase YidC -
DP17_RS03130 664599..665237 - 639 WP_002505076.1 thiamine phosphate synthase -
DP17_RS03135 665243..666031 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T48167 WP_001829980.1 NZ_CP009046:c660739-660530 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T48167 NZ_CP009046:c660739-660530 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT48167 WP_001829893.1 NZ_CP009046:c661039-660746 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT48167 NZ_CP009046:c661039-660746 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References