Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 649325..649854 Replicon chromosome
Accession NZ_CP009046
Organism Staphylococcus epidermidis strain SEI

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag DP17_RS03045 Protein ID WP_001829891.1
Coordinates 649325..649687 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag DP17_RS03050 Protein ID WP_001829931.1
Coordinates 649684..649854 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DP17_RS03025 646327..647097 - 771 WP_002440602.1 RNA polymerase sigma factor SigB -
DP17_RS03030 647072..647551 - 480 WP_038398573.1 anti-sigma B factor RsbW -
DP17_RS03035 647553..647879 - 327 WP_001829952.1 anti-sigma factor antagonist -
DP17_RS03040 647979..648980 - 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
DP17_RS03045 649325..649687 - 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DP17_RS03050 649684..649854 - 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DP17_RS03055 649941..651089 - 1149 WP_002457107.1 alanine racemase -
DP17_RS03060 651156..651509 - 354 WP_002457108.1 holo-ACP synthase -
DP17_RS03065 651557..652066 - 510 WP_002457109.1 PH domain-containing protein -
DP17_RS03070 652053..653558 - 1506 WP_002457110.1 PH domain-containing protein -
DP17_RS03075 653551..654030 - 480 WP_002457111.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T48166 WP_001829891.1 NZ_CP009046:c649687-649325 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T48166 NZ_CP009046:c649687-649325 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT48166 WP_001829931.1 NZ_CP009046:c649854-649684 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT48166 NZ_CP009046:c649854-649684 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTCCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References