Detailed information of TA system TA048143

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-MazE
• Location: 2701633..2702266
• Replicon: chromosome
• Accession: NZ_CP009040
• Organism: Xanthomonas citri pv. citri strain AW16

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: AMD06_RS12030
• Protein ID: WP_015463212.1
• Coordinates: 2701633..2702046 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M4TWF0
• Locus tag: AMD06_RS12035
• Protein ID: WP_015463213.1
• Coordinates: 2702033..2702266 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AMD06_RS12020	2697325..2699505	+	2181	WP_011051394.1	TonB-dependent siderophore receptor	-
AMD06_RS12025	2699714..2701228	+	1515	WP_015463210.1	conjugal transfer protein TraG N-terminal domain-containing protein	-
AMD06_RS24370	2701244..2701606	-	363	WP_015463211.1	DUF3742 family protein	-
AMD06_RS12030	2701633..2702046	-	414	WP_015463212.1	PIN domain-containing protein	Toxin
AMD06_RS12035	2702033..2702266	-	234	WP_015463213.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
AMD06_RS12040	2702548..2703555	+	1008	WP_199822817.1	DUF4917 family protein	-
AMD06_RS12045	2703688..2704086	-	399	WP_099521978.1	hypothetical protein	-
AMD06_RS12050	2704538..2705113	+	576	WP_011051400.1	sigma-70 family RNA polymerase sigma factor	-
AMD06_RS12055	2705094..2706143	+	1050	WP_015472205.1	FecR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-119)

Antitoxin

• SpoVT-AbrB domain (5-45)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15221.65 Da
• Isoelectric Point: 6.3225

>T48143 WP_015463212.1 NZ_CP009040:c2702046-2701633 [Xanthomonas citri pv. citri]
MAAGKGKVFLDSNVVLYLLSEDAVKADGAEALLQRRPVISVQVLNEVTHVCVRKLKMGWDEVGQFLALVRSFCKIVPLTV
DVHDRARQLAERHQLSFYDACIVAAAAIEGCQTLYSEDMHHGLIIEESLSIRNPFNV

Nucleotide

• Length: 414 bp

>T48143 NZ_CP009040:c2702046-2701633 [Xanthomonas citri pv. citri]
ATGGCCGCGGGTAAGGGCAAAGTGTTTCTCGACAGCAACGTGGTGCTCTACCTGCTGTCGGAGGATGCGGTGAAGGCGGA
CGGCGCGGAGGCATTGCTGCAGCGCAGGCCCGTCATCAGTGTGCAGGTGCTCAATGAAGTGACCCACGTCTGCGTTCGCA
AGCTCAAGATGGGCTGGGACGAAGTCGGGCAGTTCCTTGCGTTGGTGCGATCGTTCTGCAAGATAGTGCCTCTGACGGTC
GATGTTCACGACCGTGCGCGCCAGCTGGCGGAGCGGCACCAATTGTCGTTCTACGACGCGTGCATCGTGGCGGCGGCCGC
CATCGAAGGGTGCCAGACCCTCTACTCCGAAGACATGCACCACGGCCTCATCATCGAAGAGAGCCTGTCGATTCGGAACC
CGTTCAACGTCTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8663.97 Da
• Isoelectric Point: 8.7848

>AT48143 WP_015463213.1 NZ_CP009040:c2702266-2702033 [Xanthomonas citri pv. citri]
MQVAKWGNSLAVRLPSSLVEALELREGDDIEIVVDDPRLFAVRKKPGPEAMLERLRAFRGKLPADFKFNRDEANGRG

Nucleotide

• Length: 234 bp

>AT48143 NZ_CP009040:c2702266-2702033 [Xanthomonas citri pv. citri]
ATGCAAGTCGCGAAGTGGGGTAACAGCCTGGCGGTGCGCCTGCCGTCCAGTCTGGTGGAAGCGCTGGAACTGCGCGAGGG
CGACGACATCGAGATCGTCGTCGATGATCCGCGATTGTTCGCGGTGCGCAAGAAGCCGGGTCCGGAGGCCATGTTGGAGC
GGCTGCGTGCCTTCCGGGGCAAGTTGCCCGCAGATTTCAAGTTCAACCGGGACGAGGCCAATGGCCGCGGGTAA

Structures

Antitoxin

• AlphaFold DB: M4TWF0