Detailed information of TA system TA048129

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-MazE
• Location: 2701683..2702316
• Replicon: chromosome
• Accession: NZ_CP009034
• Organism: Xanthomonas citri pv. citri strain AW14

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: AMD08_RS12035
• Protein ID: WP_015463212.1
• Coordinates: 2701683..2702096 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M4TWF0
• Locus tag: AMD08_RS12040
• Protein ID: WP_015463213.1
• Coordinates: 2702083..2702316 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AMD08_RS12025	2697375..2699555	+	2181	WP_011051394.1	TonB-dependent siderophore receptor	-
AMD08_RS12030	2699764..2701278	+	1515	WP_015463210.1	conjugal transfer protein TraG N-terminal domain-containing protein	-
AMD08_RS24350	2701294..2701656	-	363	WP_015463211.1	DUF3742 family protein	-
AMD08_RS12035	2701683..2702096	-	414	WP_015463212.1	PIN domain-containing protein	Toxin
AMD08_RS12040	2702083..2702316	-	234	WP_015463213.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
AMD08_RS12045	2702598..2703605	+	1008	WP_199822817.1	DUF4917 family protein	-
AMD08_RS12050	2703738..2704136	-	399	WP_099521978.1	hypothetical protein	-
AMD08_RS12055	2704588..2705163	+	576	WP_011051400.1	sigma-70 family RNA polymerase sigma factor	-
AMD08_RS12060	2705144..2706193	+	1050	WP_015472205.1	FecR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-119)

Antitoxin

• SpoVT-AbrB domain (5-45)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15221.65 Da
• Isoelectric Point: 6.3225

>T48129 WP_015463212.1 NZ_CP009034:c2702096-2701683 [Xanthomonas citri pv. citri]
MAAGKGKVFLDSNVVLYLLSEDAVKADGAEALLQRRPVISVQVLNEVTHVCVRKLKMGWDEVGQFLALVRSFCKIVPLTV
DVHDRARQLAERHQLSFYDACIVAAAAIEGCQTLYSEDMHHGLIIEESLSIRNPFNV

Nucleotide

• Length: 414 bp

>T48129 NZ_CP009034:c2702096-2701683 [Xanthomonas citri pv. citri]
ATGGCCGCGGGTAAGGGCAAAGTGTTTCTCGACAGCAACGTGGTGCTCTACCTGCTGTCGGAGGATGCGGTGAAGGCGGA
CGGCGCGGAGGCATTGCTGCAGCGCAGGCCCGTCATCAGTGTGCAGGTGCTCAATGAAGTGACCCACGTCTGCGTTCGCA
AGCTCAAGATGGGCTGGGACGAAGTCGGGCAGTTCCTTGCGTTGGTGCGATCGTTCTGCAAGATAGTGCCTCTGACGGTC
GATGTTCACGACCGTGCGCGCCAGCTGGCGGAGCGGCACCAATTGTCGTTCTACGACGCGTGCATCGTGGCGGCGGCCGC
CATCGAAGGGTGCCAGACCCTCTACTCCGAAGACATGCACCACGGCCTCATCATCGAAGAGAGCCTGTCGATTCGGAACC
CGTTCAACGTCTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8663.97 Da
• Isoelectric Point: 8.7848

>AT48129 WP_015463213.1 NZ_CP009034:c2702316-2702083 [Xanthomonas citri pv. citri]
MQVAKWGNSLAVRLPSSLVEALELREGDDIEIVVDDPRLFAVRKKPGPEAMLERLRAFRGKLPADFKFNRDEANGRG

Nucleotide

• Length: 234 bp

>AT48129 NZ_CP009034:c2702316-2702083 [Xanthomonas citri pv. citri]
ATGCAAGTCGCGAAGTGGGGTAACAGCCTGGCGGTGCGCCTGCCGTCCAGTCTGGTGGAAGCGCTGGAACTGCGCGAGGG
CGACGACATCGAGATCGTCGTCGATGATCCGCGATTGTTCGCGGTGCGCAAGAAGCCGGGTCCGGAGGCCATGTTGGAGC
GGCTGCGTGCCTTCCGGGGCAAGTTGCCCGCAGATTTCAAGTTCAACCGGGACGAGGCCAATGGCCGCGGGTAA

Structures

Antitoxin

• AlphaFold DB: M4TWF0