Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5245473..5246140 Replicon chromosome
Accession NZ_CP009031
Organism Xanthomonas citri pv. citri strain AW13

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag AMD09_RS22885 Protein ID WP_005916679.1
Coordinates 5245724..5246140 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag AMD09_RS22880 Protein ID WP_005916676.1
Coordinates 5245473..5245727 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AMD09_RS22855 5241595..5241814 + 220 Protein_4419 RNA 2'-phosphotransferase -
AMD09_RS22860 5241971..5243236 + 1266 WP_015463799.1 cardiolipin synthase B -
AMD09_RS22865 5243262..5243789 - 528 WP_005916668.1 hypothetical protein -
AMD09_RS22870 5244028..5244234 + 207 WP_003489327.1 hypothetical protein -
AMD09_RS22875 5244221..5245327 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
AMD09_RS22880 5245473..5245727 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
AMD09_RS22885 5245724..5246140 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
AMD09_RS25855 5246262..5246534 - 273 WP_125459513.1 hypothetical protein -
AMD09_RS25860 5246593..5246805 - 213 WP_015472901.1 hypothetical protein -
AMD09_RS22890 5247062..5248681 + 1620 WP_015463800.1 hypothetical protein -
AMD09_RS22895 5248785..5249183 - 399 WP_004429277.1 DUF2384 domain-containing protein -
AMD09_RS22900 5249499..5249930 + 432 WP_005922907.1 hypothetical protein -
AMD09_RS25345 5249959..5250285 - 327 Protein_4431 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T48123 WP_005916679.1 NZ_CP009031:5245724-5246140 [Xanthomonas citri pv. citri]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T48123 NZ_CP009031:5245724-5246140 [Xanthomonas citri pv. citri]
GTGATCCTGCTCGATACCAATGTCATCTCCGAACTTTGGCGGCCTCAGCCTAATCCGCAGGTCGTCGCCTGGATCGATGC
ACAAGCTGTCGAGACACTGTTCCTGTCGGTCGTGACGGTGGCTGAACTCCGTTTCGGTATTGCCGTGATGCCCAAGGGCC
GAAAGCGATCCACCTTGCATGCTCGGTTGGAGGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGATCTG
GATGCATCACACGCATTTGCGGCGCTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACAGCAGCCGCGCAAGGATTGACCGTTGCCACTCGCGACACGGCACCATTCGAGGCGATGGCGTTAGACGTCA
TTAACCCTTGGAGTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT48123 WP_005916676.1 NZ_CP009031:5245473-5245727 [Xanthomonas citri pv. citri]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT48123 NZ_CP009031:5245473-5245727 [Xanthomonas citri pv. citri]
ATGCCTTCTTTCACCGTCCGCAATATCCCAGACGACGTGCATCGCGCGATCCGCGCGCGGGCTGCACTTCATGGCCGCAG
CACCGAAGCGGAGATCCGCGCAATCCTTGAATTGGCGGCCAAACCCGCAGACCGGGTCAAACTCGGCTCACTGCTGGTGA
GCATCGGCCGCGACGCCGGCCTGACCGCAAAAGAGGCCAATGCCTTCGACAAGCTGCGCGGCAAGGCGGCGATCAAGCCG
ATCGGTCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References