Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 4700594..4700955 Replicon chromosome
Accession NZ_CP009025
Organism Xanthomonas citri pv. citri strain BL18

Toxin (Protein)


Gene name EcnB Uniprot ID M4UGA1
Locus tag AMD12_RS20635 Protein ID WP_005914328.1
Coordinates 4700594..4700728 (-) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID H8FG64
Locus tag AMD12_RS20640 Protein ID WP_003486606.1
Coordinates 4700803..4700955 (-) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AMD12_RS20615 4695732..4697423 - 1692 WP_015471463.1 M20/M25/M40 family metallo-hydrolase -
AMD12_RS20620 4697615..4698649 - 1035 WP_011052671.1 MBL fold metallo-hydrolase -
AMD12_RS20625 4698688..4699977 - 1290 WP_015463705.1 tryptophan--tRNA ligase -
AMD12_RS20630 4700158..4700367 - 210 WP_003486601.1 CsbD family protein -
AMD12_RS20635 4700594..4700728 - 135 WP_005914328.1 entericidin A/B family lipoprotein Toxin
AMD12_RS20640 4700803..4700955 - 153 WP_003486606.1 entericidin A/B family lipoprotein Antitoxin
AMD12_RS20645 4701062..4701985 - 924 WP_005927745.1 arginase -
AMD12_RS20650 4702306..4702758 + 453 WP_003486611.1 roadblock/LC7 domain-containing protein -
AMD12_RS20655 4702822..4703181 + 360 WP_003486613.1 hypothetical protein -
AMD12_RS20660 4703278..4704195 + 918 WP_011052673.1 hypothetical protein -
AMD12_RS20665 4704192..4704734 + 543 WP_003486615.1 GTPase -
AMD12_RS20670 4705172..4705855 + 684 WP_011052674.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4459.32 Da        Isoelectric Point: 9.3487

>T48107 WP_005914328.1 NZ_CP009025:c4700728-4700594 [Xanthomonas citri pv. citri]
MKRAIVLLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T48107 NZ_CP009025:c4700728-4700594 [Xanthomonas citri pv. citri]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5122.07 Da        Isoelectric Point: 8.7942

>AT48107 WP_003486606.1 NZ_CP009025:c4700955-4700803 [Xanthomonas citri pv. citri]
MKRLLTLMVLGLFSAGVMTGCNTVAGAGKDMQGAGNKVEKTAEKCSDGKC

Download         Length: 153 bp

>AT48107 NZ_CP009025:c4700955-4700803 [Xanthomonas citri pv. citri]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCCGGCGC
CGGCAAGGACATGCAGGGTGCGGGCAACAAGGTCGAGAAAACGGCCGAAAAATGCAGCGACGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G2W7U6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YLX6

References